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  1. No Access

    Article

    Cu-catalyzed enantioselective allylic alkylation with organolithium reagents

    Cu-catalyzed asymmetric allylic alkylation (AAA) is used in the synthesis of pharmaceuticals and natural products. This protocol uses organolithium reagents in the Cu-catalyzed AAA of allylic substrates with T...

    Valentín Hornillos, Sureshbabu Guduguntla, Martín Fañanás-Mastral… in Nature Protocols (2017)

  2. Article

    Open Access

    Fast, greener and scalable direct coupling of organolithium compounds with no additional solvents

    Although the use of catalytic rather than stoichiometric amounts of metal mediator in cross-coupling reactions between organic halides and organometallic counterparts improves significantly the atom economy an...

    Erik B. Pinxterhuis, Massimo Giannerini, Valentín Hornillos… in Nature Communications (2016)

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    Chapter

    Asymmetric Allylic Substitutions Using Organometallic Reagents

    This chapter summarises recent progress in Cu-catalysed asymmetric allylic alkylation (AAA) with organometallic compounds, including Grignard, organolithium, organoaluminium, organozinc and organozirconium rea...

    Valentín Hornillos… in Progress in Enantioselective Cu(I)-catalyz… (2016)

  4. No Access

    Article

    A BODIPY-embedding miltefosine analog linked to cell-penetrating Tat(48-60) peptide favors intracellular delivery and visualization of the antiparasitic drug

    Therapeutic application of many drugs is often hampered by poor or denied access to intracellular targets. A case in point is miltefosine (MT), an orally active antiparasitic drug, which becomes ineffective w...

    Beatriz G. de la Torre, Valentín Hornillos, Juan R. Luque-Ortega… in Amino Acids (2014)