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  1. Article

    Open Access

    Longitudinal trajectories of anterior cingulate glutamate and subclinical psychotic experiences in early adolescence: the impact of bullying victimization

    Previous studies reported decreased glutamate levels in the anterior cingulate cortex (ACC) in non-treatment-resistant schizophrenia and first-episode psychosis. However, ACC glutamatergic changes in subjects ...

    Naohiro Okada, Noriaki Yahata, Daisuke Koshiyama, Kentaro Morita in Molecular Psychiatry (2024)

  2. Article

    Open Access

    Urinary exosomal microRNAs as predictive biomarkers for persistent psychotic-like experiences

    Psychotic-like experiences (PLEs) occur occasionally in adolescence and mostly disappear with increasing age. Their presence, if persistent, is considered a robust risk factor for subsequent psychiatric disord...

    Yasufumi Tomita, Kazuhiro Suzuki, Syudo Yamasaki, Kazuya Toriumi in Schizophrenia (2023)

  3. Article

    Open Access

    Hair zinc levels and psychosis risk among adolescents

    Recent meta-analyses have shown lower zinc and higher copper levels in the serum of people with schizophrenia than in healthy controls. However, the relationship between trace elements (TEs) and the pathophysi...

    Koichi Tabata, Mitsuhiro Miyashita, Syudo Yamasaki, Kazuya Toriumi in Schizophrenia (2022)

  4. Article

    Open Access

    Role of advanced glycation end products in the longitudinal association between muscular strength and psychotic symptoms among adolescents

    Muscular strength, assessed by handgrip, is a risk indicator for psychiatric disorders, including psychosis. However, the biological mechanisms underlying this association remain unclear. Since advanced glycat...

    Kazuhiro Suzuki, Syudo Yamasaki, Mitsuhiro Miyashita, Shuntaro Ando in Schizophrenia (2022)

  5. Article

    Open Access

    Fingertip advanced glycation end products and psychotic symptoms among adolescents

    Case control studies have suggested that advanced glycation end products play a key role in the pathophysiology of chronic schizophrenia. However, the longitudinal association between advanced glycation end pr...

    Mitsuhiro Miyashita, Syudo Yamasaki, Shuntaro Ando, Kazuhiro Suzuki in npj Schizophrenia (2021)

  6. Article

    Open Access

    Abnormal asymmetries in subcortical brain volume in early adolescents with subclinical psychotic experiences

    Subcortical structures may have an important role in the pathophysiology of psychosis. Our recent mega-analysis of structural magnetic resonance imaging (MRI) data has reported subcortical volumetric and later...

    Naohiro Okada, Noriaki Yahata, Daisuke Koshiyama in Translational Psychiatry (2018)

  7. Article

    Open Access

    Comprehensive early intervention for patients with first-episode psychosis in Japan (J-CAP): study protocol for a randomised controlled trial

    Comprehensive approaches for patients with psychotic symptoms play essential roles in the symptomatic and functional outcomes of patients, especially during disease onset. In Japan, the shortage of mental heal...

    Shinsuke Koike, Atsushi Nishida, Syudo Yamasaki, Kayo Ichihashi, Sanae Maegawa in Trials (2011)