-
Article
Relapsing sclerosing mesenteritis with multiple strictures of the small intestine
Sclerosing mesenteritis (SM) is a rare disorder that involves the mesenteric adipose tissue with chronic fibrosing inflammation. Few reports mention the natural history of severe SM cases. Here, we report a se...
-
Article
Open AccessLongitudinal trajectories of anterior cingulate glutamate and subclinical psychotic experiences in early adolescence: the impact of bullying victimization
Previous studies reported decreased glutamate levels in the anterior cingulate cortex (ACC) in non-treatment-resistant schizophrenia and first-episode psychosis. However, ACC glutamatergic changes in subjects ...
-
Article
Thiopurines exert harmful effects on spermatogenesis in Nudt15R138C knock-in mice
The association between thiopurine use and testicular reproductive functions remains unclear. In this study, we investigated whether thiopurines affect testicular functions based on the NUDT15 genotypes using Nud...
-
Article
Open AccessThe longitudinal relationship between dissociative symptoms and self-harm in adolescents: a population-based cohort study
Previous studies have reported that dissociative symptoms (DIS) are associated with self-harm (SH) in adolescents. However, most of these studies were cross-sectional, which limits the understanding of their t...
-
Article
The diagnostic accuracy of endoscopic ultrasound-shear wave elastography in multiple pancreatic regions for chronic pancreatitis based on the Rosemont criteria
Although endoscopic ultrasound (EUS) has been widely used for diagnosing chronic pancreatitis (CP), the assessment of fibrosis using the Rosemont criteria (RC) is generally subjective. Shear wave elastography ...
-
Article
Trajectory analyses to identify persistently low responders to COVID-19 vaccination in patients with inflammatory bowel disease: a prospective multicentre controlled study, J-COMBAT
The degree of immune response to COVID-19 vaccination in inflammatory bowel disease (IBD) patients based on actual changes in anti-SARS-CoV-2 antibody titres over time is unknown.
-
Article
Open AccessThe long-term effects of reproductive health education among primary and secondary school students: a longitudinal quasi-experimental study in rural Tanzania
Adolescent pregnancy remains a major global health issue, increasing the risk of complications during pregnancy and childbirth in mothers and babies. In Tanzania, adolescent pregnancy threatens girls’ educatio...
-
Article
Open AccessLower help-seeking intentions mediate subsequent depressive symptoms among adolescents with high autistic traits: a population-based cohort study
Adolescents with high autistic traits are at increased risk of depression. Despite the importance of seeking help for early intervention, evidence on help-seeking intentions amongst this population is scarce. ...
-
Article
Open AccessUrinary exosomal microRNAs as predictive biomarkers for persistent psychotic-like experiences
Psychotic-like experiences (PLEs) occur occasionally in adolescence and mostly disappear with increasing age. Their presence, if persistent, is considered a robust risk factor for subsequent psychiatric disord...
-
Article
Open AccessCorrection: Comparison of lithium levels between suicide and non-suicide fatalities: cross-sectional study
-
Article
Pro- and anti-inflammatory roles of interleukin (IL)-33, IL-36, and IL-38 in inflammatory bowel disease
Interleukin-33 (IL-33), IL-36, and IL-38 are members of the IL-1 cytokine family. The expression of each cytokine has been reported to be increased in the inflamed mucosa of patients with inflammatory bowel di...
-
Article
High abundance of Lachnospiraceae in the human gut microbiome is related to high immunoscores in advanced colorectal cancer
The tumor microenvironment (TME) in colorectal cancer (CRC) includes the gut microbiome, immune cells, angiogenic factors, and fibroblasts and plays a major role in cancer progression. The Immunoscore (IS) is ...
-
Article
Open AccessPredictors of chronic loneliness during adolescence: a population-based cohort study
Adolescent loneliness is a growing public health issue owing to its adverse health impact. Although adolescent loneliness is common, its trajectories can show distinct patterns over time. However, there is lim...
-
Article
Open AccessHair zinc levels and psychosis risk among adolescents
Recent meta-analyses have shown lower zinc and higher copper levels in the serum of people with schizophrenia than in healthy controls. However, the relationship between trace elements (TEs) and the pathophysi...
-
Article
Open AccessComparison of lithium levels between suicide and non-suicide fatalities: Cross-sectional study
Ecological studies have suggested the protective effect of micro-dose lithium in drinking water against suicide, however, the association between body lithium level and suicide is unknown. We aimed to compare ...
-
Article
Maternal parenting stress from birth to 36 months, maternal depressive symptoms, and physical punishment to 10-year-old children: a population-based birth cohort study
This study aimed to investigate the association between parenting stress, maternal depressive symptoms, and use of physical punishment when the child is 10 years old.
-
Article
Open AccessBidirectional relationship of problematic Internet use with hyperactivity/inattention and depressive symptoms in adolescents: a population-based cohort study
Problematic Internet use (PIU), hyperactivity/inattention, and depressive symptoms are comorbid problems in adolescence, but the causal relationships among these issues are unclear. To assess the relationships...
-
Article
Correction to: Features of the gut prokaryotic virome of Japanese patients with Crohn’s disease
-
Article
Features of the gut prokaryotic virome of Japanese patients with Crohn’s disease
The gut virome is mainly composed of bacteriophages and influences gut homeostasis and pathogenic conditions. In this study, we analyzed the gut prokaryotic virome in Japanese patients with Crohn’s disease (CD).
-
Article
Open AccessFamily caregivers’ concerns about advance care planning for home-dwelling people with dementia: a cross-sectional observational study in Japan
The importance of advance care planning for people with dementia has increased during the Coronavirus Disease 2019 Pandemic. However, family caregivers may have concerns about having conversations regarding ad...
