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Article
Open AccessLongitudinal trajectories of anterior cingulate glutamate and subclinical psychotic experiences in early adolescence: the impact of bullying victimization
Previous studies reported decreased glutamate levels in the anterior cingulate cortex (ACC) in non-treatment-resistant schizophrenia and first-episode psychosis. However, ACC glutamatergic changes in subjects ...
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Article
Open AccessThe longitudinal relationship between dissociative symptoms and self-harm in adolescents: a population-based cohort study
Previous studies have reported that dissociative symptoms (DIS) are associated with self-harm (SH) in adolescents. However, most of these studies were cross-sectional, which limits the understanding of their t...
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Article
Open AccessLower help-seeking intentions mediate subsequent depressive symptoms among adolescents with high autistic traits: a population-based cohort study
Adolescents with high autistic traits are at increased risk of depression. Despite the importance of seeking help for early intervention, evidence on help-seeking intentions amongst this population is scarce. ...
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Article
Open AccessUrinary exosomal microRNAs as predictive biomarkers for persistent psychotic-like experiences
Psychotic-like experiences (PLEs) occur occasionally in adolescence and mostly disappear with increasing age. Their presence, if persistent, is considered a robust risk factor for subsequent psychiatric disord...
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Article
Open AccessPredictors of chronic loneliness during adolescence: a population-based cohort study
Adolescent loneliness is a growing public health issue owing to its adverse health impact. Although adolescent loneliness is common, its trajectories can show distinct patterns over time. However, there is lim...
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Article
Open AccessHair zinc levels and psychosis risk among adolescents
Recent meta-analyses have shown lower zinc and higher copper levels in the serum of people with schizophrenia than in healthy controls. However, the relationship between trace elements (TEs) and the pathophysi...
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Article
Maternal parenting stress from birth to 36 months, maternal depressive symptoms, and physical punishment to 10-year-old children: a population-based birth cohort study
This study aimed to investigate the association between parenting stress, maternal depressive symptoms, and use of physical punishment when the child is 10 years old.
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Article
Open AccessBidirectional relationship of problematic Internet use with hyperactivity/inattention and depressive symptoms in adolescents: a population-based cohort study
Problematic Internet use (PIU), hyperactivity/inattention, and depressive symptoms are comorbid problems in adolescence, but the causal relationships among these issues are unclear. To assess the relationships...
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Article
Open AccessFamily caregivers’ concerns about advance care planning for home-dwelling people with dementia: a cross-sectional observational study in Japan
The importance of advance care planning for people with dementia has increased during the Coronavirus Disease 2019 Pandemic. However, family caregivers may have concerns about having conversations regarding ad...
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Article
Open AccessRole of advanced glycation end products in the longitudinal association between muscular strength and psychotic symptoms among adolescents
Muscular strength, assessed by handgrip, is a risk indicator for psychiatric disorders, including psychosis. However, the biological mechanisms underlying this association remain unclear. Since advanced glycat...
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Article
Open AccessBirth order and prosociality in the early adolescent brain
Birth order is a crucial environmental factor for child development. For example, later-born children are relatively unlikely to feel secure due to sibling competition or diluted parental resources. The positi...
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Article
Open AccessFingertip advanced glycation end products and psychotic symptoms among adolescents
Case control studies have suggested that advanced glycation end products play a key role in the pathophysiology of chronic schizophrenia. However, the longitudinal association between advanced glycation end pr...
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Article
Open AccessNeurometabolic and functional connectivity basis of prosocial behavior in early adolescence
Human prosocial behavior (PB) emerges in childhood and matures during adolescence. Previous task-related functional magnetic resonance imaging (fMRI) studies have reported involvement of the medial prefrontal ...
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Article
Open AccessAbnormal asymmetries in subcortical brain volume in early adolescents with subclinical psychotic experiences
Subcortical structures may have an important role in the pathophysiology of psychosis. Our recent mega-analysis of structural magnetic resonance imaging (MRI) data has reported subcortical volumetric and later...
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Article
Open AccessA greater number of somatic pain sites is associated with poor mental health in adolescents: a cross-sectional study
Identifying indicators of poor mental health during adolescence is a significant public health issue. Previous studies which suggested an association between the number of somatic pains and depression have mai...
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Article
Open AccessComprehensive early intervention for patients with first-episode psychosis in Japan (J-CAP): study protocol for a randomised controlled trial
Comprehensive approaches for patients with psychotic symptoms play essential roles in the symptomatic and functional outcomes of patients, especially during disease onset. In Japan, the shortage of mental heal...
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Article
Reduced gray matter volume of Brodmann’s Area 45 is associated with severe psychotic symptoms in patients with schizophrenia
Previous literature has suggested an important role of inferior frontal gyrus, which mainly consists of Brodmann’s Area (BA) 44 and 45, in the pathophysiology of schizophrenia. While recent neuroimaging techni...
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Article
Reduced planum temporale volume and delusional behaviour in patients with schizophrenia
The structural abnormality of planum temporale (PT), a part of the superior temporal heteromodal association cortex involved in auditory and language processing, has been implicated in the pathophysiology of s...
