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Open AccessClub cell protein (CC16) in serum as an effect marker for small airway epithelial damage caused by diesel exhaust and blasting fumes in potash mining
The effect marker club cell protein (CC16) is secreted by the epithelium of the small respiratory tract into its lumen and passes into the blood. Increased amounts of CC16 in serum are observed during acute ep...
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Article
Open AccessUnderground salt and potash workers exposed to nitrogen oxides and diesel exhaust: assessment of specific effect biomarkers
Occupational exposure limits (OEL) for nitrogen oxides (NO, NO2) and diesel exhaust (EC-DPM) were reassessed by the German authorities in 2016/2017. We performed a clinical cross-sectional study among salt and po...
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Open AccessAuthor’s reply to: cancer risks of firefighters: a systematic review and meta‑analysis of secular trends and region‑specific differences
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Open AccessCancer risks of firefighters: a systematic review and meta-analysis of secular trends and region-specific differences
The objective of this study was to conduct a systematic review and meta-analysis to evaluate the cancer risks among firefighters in the time course and from different geographical areas.
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Article
Open AccessCirculating long non-coding RNA GAS5 (growth arrest-specific transcript 5) as a complement marker for the detection of malignant mesothelioma using liquid biopsies
For the detection of malignant mesothelioma additional markers are needed besides the established panel consisting of calretinin and mesothelin. The aim of this study was the identification and verification of...
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Article
Mesothelin, Calretinin, and Megakaryocyte Potentiating Factor as Biomarkers of Malignant Pleural Mesothelioma
Malignant pleural mesothelioma (MPM) is a highly lethal cancer caused by exposure to asbestos. Currently, the diagnosis is a challenge, carried out by means of invasive methods of limited sensitivity. This is ...
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Open AccessAre circulating microRNAs suitable for the early detection of malignant mesothelioma? Results from a nested case–control study
Malignant mesothelioma is an aggressive cancer of the serous membranes. For the detection of the tumor at early stages non- or minimally-invasive biomarkers are needed. The circulating biomarkers miR-132-3p, m...
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Open AccessPrediagnostic detection of mesothelioma by circulating calretinin and mesothelin – a case-control comparison nested into a prospective cohort of asbestos-exposed workers
Malignant mesothelioma (MM) is strongly associated with a previous asbestos exposure. To improve timely detection of MM in asbestos workers, better screening tools – like minimally-invasive biomarkers – are de...
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Are multitasking abilities impaired in welders exposed to manganese? Translating cognitive neuroscience to neurotoxicology
Manganese (Mn) is an essential trace element with well characterized neurotoxic effects in high concentrations. Neurochemically, the initial neurotoxic effect of Mn is the perturbation of striatal γ-aminobutyr...
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Open AccessCalretinin as a blood-based biomarker for mesothelioma
Malignant mesothelioma (MM) is a deadly cancer mainly caused by previous exposure to asbestos. With a latency period up to 50 years the incidence of MM is still increasing, even in countries that banned asbest...
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Medical surveillance and long-term prognosis of occupational allergy due to platinum salts
Medical surveillance of workers in precious metals refineries and catalyst production plants is well established in many countries as a measure to prevent occupational asthma due to platinum (Pt) salts. It was...
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Open AccessOxidatively damaged guanosine in white blood cells and in urine of welders: associations with exposure to welding fumes and body iron stores
The International Agency for Research on Cancer considers the carcinogenicity of welding fume of priority for re-evaluation. Genotoxic effects in experimental animals are still inconclusive. Here, we investiga...
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A novel crossover operator based on variable importance for evolutionary multi-objective optimization with tree representation
Selecting reliable predictors has always been crucial in classification. Especially decision trees are very popular for solving supervised variable selection and classification problems. When variable selectio...
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Open AccessAir pollution and subclinical airway inflammation in the SALIA cohort study
The association between long-term exposure to air pollution and local inflammation in the lung has rarely been investigated in the general population of elderly subjects before. We investigated this associatio...
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Open AccessEvaluation of long noncoding RNA MALAT1 as a candidate blood-based biomarker for the diagnosis of non-small cell lung cancer
The long noncoding RNA MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) is described as a potential biomarker for NSCLC (non-small cell lung cancer). Diagnostic biomarkers need to be detectable in ...
