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Open AccessPortable and cost-effective genetic detection and characterization of Plasmodium falciparum hrp2 using the MinION sequencer
The prevalence of Plasmodium falciparum hrp2 (pfhrp2)-deleted parasites threatens the efficacy of the most used and sensitive malaria rapid diagnostic tests and highlights the need for continued surveillance for ...
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Open AccessAuthor Correction: The Anglo-Saxon migration and the formation of the early English gene pool
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Open AccessThe Anglo-Saxon migration and the formation of the early English gene pool
The history of the British Isles and Ireland is characterized by multiple periods of major cultural change, including the influential transformation after the end of Roman rule, which precipitated shifts in la...
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Article
Open AccessA seventeenth-century Mycobacterium tuberculosis genome supports a Neolithic emergence of the Mycobacterium tuberculosis complex
Although tuberculosis accounts for the highest mortality from a bacterial infection on a global scale, questions persist regarding its origin. One hypothesis based on modern Mycobacterium tuberculosis complex (MT...
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Article
Open AccessA treponemal genome from an historic plague victim supports a recent emergence of yaws and its presence in 15th century Europe
Developments in techniques for identification of pathogen DNA in archaeological samples can expand our resolution of disease detection. Our application of a non-targeted molecular screening tool for the parall...
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Emergence of human-adapted Salmonella enterica is linked to the Neolithization process
It has been hypothesized that the Neolithic transition towards an agricultural and pastoralist economy facilitated the emergence of human-adapted pathogens. Here, we recovered eight Salmonella enterica subsp. ent...
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Open AccessDifferential preservation of endogenous human and microbial DNA in dental calculus and dentin
Dental calculus (calcified dental plaque) is prevalent in archaeological skeletal collections and is a rich source of oral microbiome and host-derived ancient biomolecules. Recently, it has been proposed that ...
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Article
Salmonella enterica genomes from victims of a major sixteenth-century epidemic in Mexico
Indigenous populations of the Americas experienced high mortality rates during the early contact period as a result of infectious diseases, many of which were introduced by Europeans. Most of the pathogenic ag...
