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Open AccessMetagenomic and paleopathological analyses of a historic documented collection explore ancient dental calculus as a diagnostic tool
Dental calculus is a microbial biofilm that contains biomolecules from oral commensals and pathogens, including those potentially related to cause of death (CoD). To assess the utility of calculus as a diagnos...
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Open AccessDental caries and its association with the oral microbiomes and HIV in young children—Nigeria (DOMHaIN): a cohort study
This study seeks to understand better the mechanisms underlying the increased risk of caries in HIV-infected school-aged Nigerian children by examining the relationship between the plaque microbiome and perina...
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Open AccessDifferential preservation of endogenous human and microbial DNA in dental calculus and dentin
Dental calculus (calcified dental plaque) is prevalent in archaeological skeletal collections and is a rich source of oral microbiome and host-derived ancient biomolecules. Recently, it has been proposed that ...
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Open AccessCorrection: Corrigendum: Intrinsic challenges in ancient microbiome reconstruction using 16S rRNA gene amplification
Scientific Reports 5: Article number: 16498; Published online: 13 November 2015; Updated: 02 June 2016 The Acknowledgements section in this Article is incomplete. “This work was supported by the European Resea...
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Open AccessIntrinsic challenges in ancient microbiome reconstruction using 16S rRNA gene amplification
To date, characterization of ancient oral (dental calculus) and gut (coprolite) microbiota has been primarily accomplished through a metataxonomic approach involving targeted amplification of one or more varia...
