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Article
Open AccessA robust and interpretable machine learning approach using multimodal biological data to predict future pathological tau accumulation
The early stages of Alzheimer’s disease (AD) involve interactions between multiple pathophysiological processes. Although these processes are well studied, we still lack robust tools to predict individualised ...
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Article
Open AccessAge, vascular disease, and Alzheimer’s disease pathologies in amyloid negative elderly adults
We recently reported that CSF phosphorylated tau (p-Tau181) relative to Aβ40 (CSF p-Tau/Aβ40 ratio) was less noisy and increased associations with Alzheimer’s disease (AD) biomarkers compared to CSF p-Tau181 alon...
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Article
Open AccessValidation of amyloid PET positivity thresholds in centiloids: a multisite PET study approach
Inconsistent positivity thresholds, image analysis pipelines, and quantitative outcomes are key challenges of multisite studies using more than one β-amyloid (Aβ) radiotracer in positron emission tomography (P...
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Article
Open AccessEarly detection of amyloid load using 18F-florbetaben PET
A low amount and extent of Aβ deposition at early stages of Alzheimer’s disease (AD) may limit the use of previously developed pathology-proven composite SUVR cutoffs. This study aims to characterize the popul...
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Article
Open AccessNormalization of CSF pTau measurement by Aβ40 improves its performance as a biomarker of Alzheimer’s disease
Alzheimer’s disease (AD)-related tauopathy can be measured with CSF phosphorylated tau (pTau) and tau PET. We aim to investigate the associations between these measurements and their relative ability to predic...
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Article
Sequence learning in pianists and nonpianists: An fMRI study of motor expertise
Previous studies of motor learning have proposed a distinction between fast and slow learning, but these mechanisms have rarely been examined simultaneously. We examined the influence of longterm motor experti...
