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  1. Article

    Open Access

    TRAIL-induced programmed necrosis as a novel approach to eliminate tumor cells

    The cytokine TRAIL represents one of the most promising candidates for the apoptotic elimination of tumor cells, either alone or in combination therapies. However, its efficacy is often limited by intrinsic or...

    Susann Voigt, Stephan Philipp, Parvin Davarnia, Supandi Winoto-Morbach… in BMC Cancer (2014)

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  2. No Access

    Chapter and Conference Paper

    Compartmentalization of TNF-Receptor 1 Signaling: TNF-R1-Associated Caspase-8 Mediates Activation of Acid Sphingomyelinase in Late Endosomes

    Tumor necrosis factor-α (TNF-α) is known as a highly pleiotropic cytokine. Stimulation of TNF-receptor 1 (TNF-R1) by TNF-α elicits the transduction of intracellular signals that on the one side promote cell de...

    Uwe Bertsch, Bärbel Edelmann, Vladimir Tchikov… in Advances in TNF Family Research (2011)

  3. No Access

    Article

    PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide

    Platelet-activating factor (PAF) induces pulmonary edema and has a key role in acute lung injury (ALI). Here we show that PAF induces pulmonary edema through two mechanisms: acid sphingomyelinase (ASM)-depende...

    Rolf Göggel, Supandi Winoto-Morbach, Gabriele Vielhaber, Yumiko Imai… in Nature Medicine (2004)

  4. No Access

    Chapter

    Ceramide as an Activator Lipid of Cathepsin D

    We have identified the aspartic protease cathepsin D as a novel intracellular target protein for the lipid second messenger ceramide. Ceramide specifically binds to and induces CTSD proteolytic activity. A-SMa...

    Michael Heinrich, Marc Wickel… in Cellular Peptidases in Immune Functions an… (2002)

  5. No Access

    Chapter

    Synthesis Studies on Paramagnetic Polystyrene Latex Particles

    Radical polymerization in emulsion and in dispersion was applied to incorporate colloidal paramagnetic material into polystyrene latex particles. In emulsion, freshly precipitated magnetite (FeO · Fe2O3 = Fe3O4) ...

    Bernd-R. Paulke, Norbert Buske… in Scientific and Clinical Applications of Ma… (1997)