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Article
Open AccessEffect of orthodontic treatment on the periapical radiolucency of endodontically treated teeth: a CBCT analysis
This study aimed to evaluate periapical radiolucency of endodontically treated teeth before and after orthodontic treatment using cone-beam computed tomography (CBCT).
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Article
Deubiquitinase OTUD5 is a positive regulator of mTORC1 and mTORC2 signaling pathways
The mammalian Target of Rapamycin (mTOR) pathway regulates a variety of physiological processes, including cell growth and cancer progression. The regulatory mechanisms of these signals are extremely complex a...
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Article
Open AccessDisordered region of cereblon is required for efficient degradation by proteolysis-targeting chimera
Proteolysis targeting chimeras (PROTACs) are an emerging strategy for promoting targeted protein degradation by inducing the proximity between targeted proteins and E3 ubiquitin ligases. Although successful de...
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Article
Facile ring opening reaction of oxazolone enables efficient amidation for aminoisobutyric acid
4,4-Dimethyloxazolones derived from N-protected aminoisobutyric acid (AIB) are particularly known as poor electrophiles due to the steric hindrance around the carbonyl and not employed as useful intermediates for...
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Article
An efficient synthetic protocol for amide derivatives of Boc-2-aminoisobutyrate
Aminoisobutyric acid (AIB) is an important building block widely incorporated by medicinal chemists in molecular design. Owing to the steric challenge, elaborating AIB’s carboxylic acid using conventional amid...
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Article
Leucine-rich repeat-containing G-protein coupled receptor 5/GPR49 activates G12/13-Rho GTPase pathway
Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5/GPR49) is highly expressed in adult stem cells of various tissues, such as intestine, hair follicles, and stomach. LGR5 is also overexpressed i...
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Article
A novel therapeutic target, GPR43; Where it stands in drug discovery
With growing interest in human microbiome for its implication in metabolic disorders, inflammatory diseases, immune disorders and so forth, understanding the biology at the interface of the gut flora and the h...
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Article
Optimized algorithm for balancing clusters in wireless sensor networks
Wireless sensor networks consist of hundreds or thousands of sensor nodes that involve numerous restrictions including computation capability and battery capacity. Topology control is an important issue for ac...
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Article
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
The PINK1 gene was recently implicated in autosomal recessive juvenile Parkinson's disease. Two groups have studied the equivalent gene in the fruitfly Drosophila, and find that it localizes to mitochondria in vi...
