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  1. Article

    Open Access

    Discovery of a peripheral 5HT2A antagonist as a clinical candidate for metabolic dysfunction-associated steatohepatitis

    Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is currently the leading cause of chronic liver disease worldwide. Metabolic Dysfunction-Associated Steatohepatitis (MASH), an advanced form of ...

    Haushabhau S. Pagire, Suvarna H. Pagire, Byung-kwan Jeong… in Nature Communications (2024)

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  2. No Access

    Article

    AK2 activates a novel apoptotic pathway through formation of a complex with FADD and caspase-10

    Mitochondrial proteins function as essential regulators in apoptosis. Here, we show that mitochondrial adenylate kinase 2 (AK2) mediates mitochondrial apoptosis through the formation of an AK2–FADD–caspase-10 ...

    Ho-June Lee, Jong-Ok Pyo, Yumin Oh, Hyo-** Kim, Se-hoon Hong… in Nature Cell Biology (2007)

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    Chapter

    Ubiquitin and Intracellular Aggregation

    The ubiquitin-proteasome system (UPS) is involved in many biological pathways via the degradation of short-lived and regulatory proteins important in cellular processes. Moreover, in the most of the chronic hu...

    Sungmin Song, Yong-Keun Jung in Molecular Mechanisms of Programmed Cell Death (2003)