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Article
Open AccessAK2 is an AMP-sensing negative regulator of BRAF in tumorigenesis
The RAS–BRAF signaling is a major pathway of cell proliferation and their mutations are frequently found in human cancers. Adenylate kinase 2 (AK2), which modulates balance of adenine nucleotide pool, has been im...
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Article
Open AccessAberrant role of ALK in tau proteinopathy through autophagosomal dysregulation
Proteinopathy in neurodegenerative diseases is typically characterized by deteriorating activity of specific protein aggregates. In tauopathies, including Alzheimer’s disease (AD), tau protein abnormally accum...
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Article
Open AccessTriamterene induces autophagic degradation of lysosome by exacerbating lysosomal integrity
The maintenance of lysosomal integrity is essential for lysosome function and cell fate. Damaged lysosomes are degraded by lysosomal autophagy, lysophagy. The mechanism underlying lysophagy remains largely unk...
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Article
Open AccessIncreased O-GlcNAcylation of Drp1 by amyloid-beta promotes mitochondrial fission and dysfunction in neuronal cells
As a dynamic organelle, mitochondria continuously fuse and divide with adjacent mitochondria. Imbalance in mitochondria dynamics leads to their dysfunction, which implicated in neurodegenerative diseases. Howe...
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Article
Open AccessPrimary cilia mediate mitochondrial stress responses to promote dopamine neuron survival in a Parkinson’s disease model
A primary cilium is an antenna-like structure on the cell surface that plays a crucial role in sensory perception and signal transduction. Mitochondria, the ‘powerhouse’ of the cell, control cell survival, and...
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Article
Open AccessCasein kinase-1γ1 and 3 stimulate tumor necrosis factor-induced necroptosis through RIPK3
Upon necroptosis activation, receptor interacting serine/threonine kinase (RIPK)1 and RIPK3 form a necrosome complex with pseudokinase mixed lineage kinase-like (MLKL). Although protein phosphorylation is a ke...
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Article
Open AccessCardioprotective role of APIP in myocardial infarction through ADORA2B
In ischemic human hearts, the induction of adenosine receptor A2B (ADORA2B) is associated with cardioprotection against ischemic heart damage, but the mechanism underlying this association remains unclear. Apa...
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Article
Open AccessPhosphorylated CAV1 activates autophagy through an interaction with BECN1 under oxidative stress
CAV1/Caveolin1, an integral membrane protein, is involved in caveolae function and cellular signaling pathways. Here, we report that CAV1 is a positive regulator of autophagy under oxidative stress and cerebra...
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Article
Open AccessRegulation of anoikis resistance by NADPH oxidase 4 and epidermal growth factor receptor
Normal cells are sensitive to anoikis, which is a cell detachment-induced apoptosis. However, cancer cells acquire anoikis resistance that is essential for successful metastasis. This study aimed to demonstrat...
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Article
ENC1 Modulates the Aggregation and Neurotoxicity of Mutant Huntingtin Through p62 Under ER Stress
Huntington’s disease (HD) is a devastating neurodegenerative disorder, which is caused by the expression and aggregation of polyQ-expanded mutant huntingtin protein (mtHTT). While toxic mtHTT aggregates are pr...
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Article
Open AccessE2-25K SUMOylation inhibits proteasome for cell death during cerebral ischemia/reperfusion
Cerebral ischemia/reperfusion (I/R) causes brain damage accompanied by ubiquitin accumulation and impairment of proteasome activity. In this study, we report that E2-25K, an E2-conjugating enzyme, is SUMOylate...
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Article
Open AccessiRhom1 regulates proteasome activity via PAC1/2 under ER stress
Proteasome is a protein degradation complex that plays a major role in maintaining cellular homeostasis. Despite extensive efforts to identify protein substrates that are degraded through ubiquitination, the r...
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Article
Amyloid beta receptors responsible for neurotoxicity and cellular defects in Alzheimer’s disease
Alzheimer’s disease (AD) is the most common neurodegenerative disease. Although a major cause of AD is the accumulation of amyloid-β (Aβ) peptide that induces neuronal loss and cognitive impairments, our under...
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Article
OCIAD2 activates γ-secretase to enhance amyloid β production by interacting with nicastrin
The gamma (γ)-secretase holoenzyme is composed of four core proteins and cleaves APP to generate amyloid beta (Aβ), a key molecule that causes major neurotoxicity during the early stage of Alzheimer’s disease ...
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Article
Open AccessThe DUSP26 phosphatase activator adenylate kinase 2 regulates FADD phosphorylation and cell growth
Adenylate kinase 2 (AK2), which balances adenine nucleotide pool, is a multi-functional protein. Here we show that AK2 negatively regulates tumour cell growth. AK2 forms a complex with dual-specificity phospha...
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Article
Open AccessFcgRIIb mediates amyloid-β neurotoxicity and memory impairment in a model of Alzheimer’s disease
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Article
Open AccessOverexpression of Atg5 in mice activates autophagy and extends lifespan
Autophagy has been implicated in the ageing process, but whether autophagy activation extends lifespan in mammals is unknown. Here we show that ubiquitous overexpression of Atg5, a protein essential for autoph...
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Article
Open AccessMolecules and their functions in autophagy
Autophagy is a self-degradation system of cellular components through an autophagosomal-lysosomal pathway. Over the last 15 yr, yeast genetic screens led to the identification of a number of genes involved in ...
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Article
Amyloid β-induced FOXRED2 mediates neuronal cell death via inhibition of proteasome activity
Proteasome inhibition has been regarded as one of the mediators of Aβ neurotoxicity. In this study, we found that FOXRED2, a novel endoplasmic reticulum (ER) residential protein, is highly up-regulated by Aβ i...
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Article
AK2 activates a novel apoptotic pathway through formation of a complex with FADD and caspase-10
Mitochondrial proteins function as essential regulators in apoptosis. Here, we show that mitochondrial adenylate kinase 2 (AK2) mediates mitochondrial apoptosis through the formation of an AK2–FADD–caspase-10 ...
