34 Result(s)
within
Sung-soo Kim
Biomedicine, general
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Article
Open AccessEffects of cadmium on glucose transport in rat adipocytes and human erythrocytes: stimulation of GLUT1 catalytic activity
The effects of cadmium on facilitative glucose transporter function In rat adipocytes were studied. A short (30 min) incubation with cadmium resulted in stimulation of 3-O-methyl-D-glucose (3OMG ) equilibrium ...
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Open AccessRapid increase of cytosolic content of acetyl-CoA carboxylase isoforms in H9c2 cells by short-term treatment with insulin and okadaic acid
Mammalian acetyl-CoA carboxylase (ACC) is present in two isoforms, α and β, both of which catalyze formation of malonyl-CoA by fixing CO2 into acetyl-CoA. ACC-α is highly expressed in lipogenic tissues whereas...
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Open AccessHeterogeneous HBV mutants coexist in Korean hepatitis B patients
Although many hepatitis B virus (HBV) mutants have been found in all open reading frames since the precore defective mutant was initially reported, systematic investigations of diverse HBV mutant populations i...
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Open AccessThe regulatory mechanism of phosphatidylinositol 3-kinase by insulin in 3T3 L1 fibroblasts: phosphorylation-independent activation of phosphatidylinositol 3-kinase
Phosphatidylinositol (PI) 3-kinase plays an important role in transducing the signals of various growth factor receptors. However, the regulatory mechanism of PI3-kinase activity by these growth factor recepto...
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Open AccessOverexpression of neurogenin1 induces neurite outgrowth in F11 neuroblastoma cells
Neurogenin1 (Ngn1) is a basic helix-loop-helix (bHLH) transcription factor expressed in neuronal precursors in the develo** nervous system. The function of Ngn1 in neurogenesis has been shown in various aspe...
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Pott's paraplegia in patients with severely deformed dorsal or dorsolumbar spines: treatment and prognosis
Study design: Pott's paraplegic patients with severe spinal deformity were reviewed retrospectively after being treated with chemotherapy and/or decompressive surgery.
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Open AccessForskolin promotes astroglial differentiation of human central neurocytoma cells
Human central neurocytoma is a kind of the brain tumors that are usually found in anterior part of the lateral ventricles. In this study, we established conditions that allowed proliferation of neurocytoma cel...
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Open AccessResveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase
trans-Resveratrol (t-RVT), a naturally occurring polyphenol found in Polygonum cuspidatum, grape, and red wine, has been reported to have anti- inflammatory, cardioprotective, and cancer chemopreventive propertie...
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Open AccessCyclooxygenase-2 promotes cell proliferation, migration and invasion in U2OS human osteosarcoma cells
Osteosarcoma is the most common primary bone tumor, but the pathogenesis is not well understood. While cyclooxygeanse-2 (COX-2) is known to be closely associated with tumor growth and metastasis in several kin...
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Open AccessMesenchymal stem cells promote proliferation of endogenous neural stem cells and survival of newborn cells in a rat stroke model
Mesenchymal stem cells (MSCs) secrete bioactive factors that exert diverse responses in vivo. In the present study, we explored mechanism how MSCs may lead to higher functional recovery in the animal stroke model...
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Article
Successful application of the dual-vector system II in creating a reliable phage-displayed combinatorial Fab library
The dual-vector system-II (DVS-II), which allows efficient display of Fab antibodies on phage, has been reported previously, but its practical applicability in a phage-displayed antibody library has not been v...
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Open AccessThe function of p27KIP1 during tumor development
Timely cell cycle regulation is conducted by sequential activation of a family of serine-threonine kinases called cycle dependent kinases (CDKs). Tight CDK regulation involves cyclin dependent kinase inhibitor...
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Open AccessMacronutrient intake induces oxidative and inflammatory stress: potential relevance to atherosclerosis and insulin resistance
With the global increase in the epidemic of obesity and type 2 diabetes with a concomitant increase in atherosclerotic disease, an investigation into the effects of various macronutrients and food products has...
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Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians
Norihiro Kato and colleagues perform a meta-analysis of genome-wide association studies to identify common variants associated with blood pressure variation in east Asians. They identify five new genome-wide s...
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Article
Epidemiological profiles between equol producers and nonproducers: a genomewide association study of the equol-producing phenotype
Equol is a daidzein (a phytoestrogen isoflavone) metabolite of gut bacteria, and the ability to produce equol varies between individuals and reduces the risks of several diseases. We tested the effects of equo...
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Open AccessRetrovirus-mediated transduction of a cytosine deaminase gene preserves the stemness of mesenchymal stem cells
Human mesenchymal stem cells (MSCs) have emerged as attractive cellular vehicles to deliver therapeutic genes for ex-vivo therapy of diverse diseases; this is, in part, because they have the capability to migrate...
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Open AccessMitochondria-targeted antioxidant MitoQ ameliorates experimental mouse colitis by suppressing NLRP3 inflammasome-mediated inflammatory cytokines
MitoQ is a mitochondria-targeted derivative of the antioxidant ubiquinone, with antioxidant and anti-apoptotic functions. Reactive oxygen species are involved in many inflammatory diseases including inflammato...
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A case of inoperable klatskin tumor showing response to wild ginseng pharmacopuncture
Klatskin tumor is known to be highly resistant to conventional chemotherapy and radiotherapy. Although surgical resection is the treatment of choice if possible, the prognosis is very poor after the surgery. I...
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Article
Open AccessCancer cell metabolism: implications for therapeutic targets
Cancer cell metabolism is characterized by an enhanced uptake and utilization of glucose, a phenomenon known as the Warburg effect. The persistent activation of aerobic glycolysis in cancer cells can be linked...
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Open AccessSimultaneous deletion of floxed genes mediated by CaMKIIα-Cre in the brain and in male germ cells: application to conditional and conventional disruption of Goα
The Cre/LoxP system is a well-established approach to spatially and temporally control genetic inactivation. The calcium/calmodulin-dependent protein kinase II alpha subunit (CaMKIIα) promoter limits expressio...
