18 Result(s)
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Open AccessEffects of cadmium on glucose transport in rat adipocytes and human erythrocytes: stimulation of GLUT1 catalytic activity
The effects of cadmium on facilitative glucose transporter function In rat adipocytes were studied. A short (30 min) incubation with cadmium resulted in stimulation of 3-O-methyl-D-glucose (3OMG ) equilibrium ...
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Open AccessRapid increase of cytosolic content of acetyl-CoA carboxylase isoforms in H9c2 cells by short-term treatment with insulin and okadaic acid
Mammalian acetyl-CoA carboxylase (ACC) is present in two isoforms, α and β, both of which catalyze formation of malonyl-CoA by fixing CO2 into acetyl-CoA. ACC-α is highly expressed in lipogenic tissues whereas...
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Open AccessHeterogeneous HBV mutants coexist in Korean hepatitis B patients
Although many hepatitis B virus (HBV) mutants have been found in all open reading frames since the precore defective mutant was initially reported, systematic investigations of diverse HBV mutant populations i...
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Open AccessThe regulatory mechanism of phosphatidylinositol 3-kinase by insulin in 3T3 L1 fibroblasts: phosphorylation-independent activation of phosphatidylinositol 3-kinase
Phosphatidylinositol (PI) 3-kinase plays an important role in transducing the signals of various growth factor receptors. However, the regulatory mechanism of PI3-kinase activity by these growth factor recepto...
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Open AccessOverexpression of neurogenin1 induces neurite outgrowth in F11 neuroblastoma cells
Neurogenin1 (Ngn1) is a basic helix-loop-helix (bHLH) transcription factor expressed in neuronal precursors in the develo** nervous system. The function of Ngn1 in neurogenesis has been shown in various aspe...
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Open AccessForskolin promotes astroglial differentiation of human central neurocytoma cells
Human central neurocytoma is a kind of the brain tumors that are usually found in anterior part of the lateral ventricles. In this study, we established conditions that allowed proliferation of neurocytoma cel...
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Open AccessResveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase
trans-Resveratrol (t-RVT), a naturally occurring polyphenol found in Polygonum cuspidatum, grape, and red wine, has been reported to have anti- inflammatory, cardioprotective, and cancer chemopreventive propertie...
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Open AccessCyclooxygenase-2 promotes cell proliferation, migration and invasion in U2OS human osteosarcoma cells
Osteosarcoma is the most common primary bone tumor, but the pathogenesis is not well understood. While cyclooxygeanse-2 (COX-2) is known to be closely associated with tumor growth and metastasis in several kin...
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Open AccessMesenchymal stem cells promote proliferation of endogenous neural stem cells and survival of newborn cells in a rat stroke model
Mesenchymal stem cells (MSCs) secrete bioactive factors that exert diverse responses in vivo. In the present study, we explored mechanism how MSCs may lead to higher functional recovery in the animal stroke model...
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Open AccessThe function of p27KIP1 during tumor development
Timely cell cycle regulation is conducted by sequential activation of a family of serine-threonine kinases called cycle dependent kinases (CDKs). Tight CDK regulation involves cyclin dependent kinase inhibitor...
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Open AccessMacronutrient intake induces oxidative and inflammatory stress: potential relevance to atherosclerosis and insulin resistance
With the global increase in the epidemic of obesity and type 2 diabetes with a concomitant increase in atherosclerotic disease, an investigation into the effects of various macronutrients and food products has...
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Open AccessRetrovirus-mediated transduction of a cytosine deaminase gene preserves the stemness of mesenchymal stem cells
Human mesenchymal stem cells (MSCs) have emerged as attractive cellular vehicles to deliver therapeutic genes for ex-vivo therapy of diverse diseases; this is, in part, because they have the capability to migrate...
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Open AccessCancer cell metabolism: implications for therapeutic targets
Cancer cell metabolism is characterized by an enhanced uptake and utilization of glucose, a phenomenon known as the Warburg effect. The persistent activation of aerobic glycolysis in cancer cells can be linked...
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Open AccessSimultaneous deletion of floxed genes mediated by CaMKIIα-Cre in the brain and in male germ cells: application to conditional and conventional disruption of Goα
The Cre/LoxP system is a well-established approach to spatially and temporally control genetic inactivation. The calcium/calmodulin-dependent protein kinase II alpha subunit (CaMKIIα) promoter limits expressio...
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Open AccessTherapeutic effect of hepatocyte growth factor-secreting mesenchymal stem cells in a rat model of liver fibrosis
Bone marrow-derived mesenchymal stromal cells (MSCs) have been reported to be beneficial for the treatment of liver fibrosis. Here, we investigated the use of genetically engineered MSCs that overexpress hepat...
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Open AccessMelatonin prevents doxorubicin-induced cardiotoxicity through suppression of AMPKα2-dependent mitochondrial damage
The clinical application of doxorubicin, one of the most effective anticancer drugs, has been limited due to its adverse effects, including cardiotoxicity. One of the hallmarks of doxorubicin-induced cytotoxic...
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Open AccessDevelopment of a miRNA-controlled dual-sensing system and its application for targeting miR-21 signaling in tumorigenesis
MicroRNAs (miRNAs) are considered to be strong prognostic markers and key therapeutic targets in human diseases, especially cancer. A sensitive monitoring platform for cancer-associated miRNA (oncomiR) action ...
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Open AccessMelatonin and doxorubicin synergistically enhance apoptosis via autophagy-dependent reduction of AMPKα1 transcription in human breast cancer cells
Doxorubicin is one of the most effective agents used to treat various cancers, including breast cancer, but its usage is limited by the risk of adverse effects, including cardiotoxicity. Melatonin, a natural h...
