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Article
Curcumin Encapsulated Micellar Nanoplatform for Blue Light Emitting Diode Induced Apoptosis as a New Class of Cancer Therapy
Blue light emitting diode (BLED) were known to inhibit cancer proliferation and induced apoptotic cell death by increasing intracellular reactive oxygen species (ROS) and caspase activation. However, not many ...
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Article
Modulation in Natriuretic Peptides System in Experimental Colitis in Rats
Renin-angiotensin system is involved in the pathophysiology of colonic inflammation. However, there are a few reports about modulation of natriuretic peptide system.
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Article
Scintigraphic evaluation of therapeutic angiogenesis induced by VEGF-loaded chitosan nanoparticles in a rodent model of hindlimb ischemia
We examined the therapeutic effect of chitosan nanoparticles (CHI) incorporating vascular endothelial growth factor (VEGF) on hindlimb ischemia using single photon emission computed tomography (SPECT) perfusio...
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Article
Reactive oxygen species, glutathione, and thioredoxin influence suberoyl bishydroxamic acid-induced apoptosis in A549 lung cancer cells
Suberoyl bishydroxamic acid (SBHA) as a histone deacetylase (HDAC) inhibitor can induce apoptosis through the formation of reactive oxygen species (ROS). However, there is no report about the regulation of ROS...
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Article
Open AccessInhibition of Janus activated kinase-3 protects against myocardial ischemia and reperfusion injury in mice
Recent studies have documented that Janus-activated kinase (JAK)–signal transducer and activator of transcription (STAT) pathway can modulate the apoptotic program in a myocardial ischemia/reperfusion (I/R) mo...
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Article
Arsenic trioxide induces human pulmonary fibroblast cell death via the regulation of Bcl-2 family and caspase-8
Arsenic trioxide (ATO; As2O3) can induce apoptotic cell death in various cancer cells including lung cancer cells. However, little is known about the toxicological effects of ATO on normal primary lung cells. In ...
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Article
Gallic acid-induced lung cancer cell death is accompanied by ROS increase and glutathione depletion
Gallic acid (GA) is generally distributed in a variety of plants and foods, and its various biological effects have been reported. Here, we investigated the effects of GA and/or caspase inhibitors on Calu-6 an...
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Article
A Comparison of the Lipolytic Activity of Different Natriuretic Peptides on Human Adipocytes
Atrial natriuretic peptide (ANP) was recently shown to promote triacylglycerol hydrolysis in human white adipocytes both in vitro and in vivo through a cGMP-dependent pathway. The ANP-stimulated lipolytic effe...
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Article
Endogenous nitric oxide mechanisms mediate the stretch dependence of Ca2+ release in cardiomyocytes
Stretching of cardiac muscle modulates contraction through the enhancement of the Ca2+ transient, but how this occurs is still not known. We found that stretching of myocytes modulates the elementary Ca2+ release...
