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Article
Glycol Chitosan-Astaxanthin Nanoparticles: Water Dispersion, Antioxidant Activity, and Improved Cell Migration
Nanoparticle formulation is very important for broadening the bioavailability of astaxanthin (AXT) in biomedical fields. In this study, glycol chitosan (GC)-decorated AXT nanoparticles (GC-AXT nanoparticles) s...
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Article
C-Phycoycanin-Doxorubicin Nanoparticles for Chemo-Photodynamic Cancer Therapy
C-Phycocyanin (CPC) obtained from Spirulina platensis is a natural blue dye and is attracting attention due to its photodynamic activity, anti-inflammatory effect and anti-cancer properties. The aim of this study...
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Article
Open AccessNIR-Mediated drug release and tumor theranostics using melanin-loaded liposomes
Heat generation in a drug delivery carrier by exposure to near-infrared (NIR) light with excellent tissue transmittance is an effective strategy for drug release and tumor therapy. Because liposomes have amphi...
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Article
Near-Infrared Laser-Responsive Photothermal Bubble-Generating PLA Nanoparticles for Controlled Drug Release
Stimuli-responsive drug delivery systems can respond to specific external stimuli, resulting in improved treatment outcomes and reduced side effects from their controllable site-specific release ability. The a...
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Article
Transdermal Hydrogel Composed of Polyacrylic Acid Containing Propolis for Wound Healing in a Rat Model
The aim of this study was to investigate the effect of the Carbopol® hydrogel containing propolis (CHP) on wound healing in a rat model. CHP extracts inhibited nitric oxide production induced by lipopolysaccha...
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Article
The Alginate Layer for Improving Doxorubicin Release and Radiolabeling Stability of Chitosan Hydrogels
Chitosan hydrogels (CSH) formed through ionic interaction with an anionic molecule are suitable as a drug carrier and a tissue engineering scaffold. However, the initial burst release of drugs from the CSH due...
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Article
Improved suspension stability of calcium carbonate nanoparticles by surface modification with oleic acid and phospholipid
We prepared and characterized calcium carbonate nanoparticles (CC NPs) that were surface-modified with oleic acid (OA) and phosphatidylcholine (PC) in order to improve their suspension stability in an aqueous ...
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Article
Scintigraphic evaluation of therapeutic angiogenesis induced by VEGF-loaded chitosan nanoparticles in a rodent model of hindlimb ischemia
We examined the therapeutic effect of chitosan nanoparticles (CHI) incorporating vascular endothelial growth factor (VEGF) on hindlimb ischemia using single photon emission computed tomography (SPECT) perfusio...
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Article
Effect of Angiogenesis Induced by Consecutive Intramuscular Injections of Vascular Endothelial Growth Factor in a Hindlimb Ischemic Mouse Model
Angiogenesis plays a major role in various physiological and pathological situations. Thus, an angiogenic therapy with vascular endothelial growth factor (VEGF) has been commonly recommended as a representativ...
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Article
Radiolabeled chitosan hydrogel containing VEGF enhances angiogenesis in a rodent model of acute myocardial infarction
Vascular endothelial growth factor (VEGF) plays a pivotal role in angiogenesis in an infarcted myocardium. The purpose of the current investigation was to validate whether a radiolabeled VEGF delivery system c...
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Article
The effect of caseinate on inclusion complexes of γ-cyclodextrin for oxidative stabilization of fish oil
In this study, we investigated that when γ-cyclodextrin (γ-CD) forms the inclusion complexes for fish oils, the oxidation stability and retardation of odor can be effectively enhanced through the addition of sodi...
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Article
Prevention of post-surgical peritoneal adhesion in rats using curdlan and gellan gum hydrogels
The prevention of undesired abdominal wall adhesion after surgery was investigated using polysaccharide hydrogels as physical barriers. Hydrogels of curdlan, gellan gum, and a mixture of the two were prepared ...
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Article
Prostate Cancer-Targeted Imaging Using Magnetofluorescent Polymeric Nanoparticles Functionalized with Bombesin
In this work, the aim was to prepare and characterize a magnetofluorescent polymeric nanoparticle for prostate cancer imaging in vivo.
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Article
Synthesis and characterization of iron oxide nanoparticles decorated with carboxymethyl curdlan
We have synthesized the SPION coated with CMC and investigated the stability in water,T 2 relaxation rate and cytotoxicity. The coating with CMC improved the stability in water and reduced the cyt...
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Article
Molecular scintigraphic imaging using 99mTc–transferrin is useful for early detection of synovial inflammation of collagen-induced arthritis mouse
Transferrin receptor (TfR) is highly expressed on rapidly dividing inflammatory cells, but not in nonproliferating cells. We investigated whether scintigraphic imaging using 99mTechnetium-radiolabeled transferrin...
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Article
Temperature-induced release of all-trans-retinoic acid loaded in solid lipid nanoparticles for topical delivery
The aim of this work was to develop and evaluate solid lipid nanoparticles (SLN) containing all-trans-retinoic acid (ATRA) for topical delivery. SLN composed of coconut oil and curdlan improved the suspension ins...
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Article
Alginate/carboxymethyl scleroglucan hydrogels for controlled release of protein drugs
Alginate/carboxymethyl scleroglucan (CMSG) hydrogels were suggested as a novel carrier for the controlled release of protein drugs. The drug release characteristics of alginate hydrogels were improved by CMSG ...
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Article
Controlled release of cyclosporin A from liposomes-in-microspheres as an oral delivery system
The aim of this study was to prepare cyclosporin A-loaded liposome (CyA-Lip) as an oral delivery carrier, with their encapsulation into microspheres based on alginate or extracellular polysaccharide (EPS) p-m ...
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Article
Preparation and mucoadhesive test of CSA-loaded liposomes with different characteristics for the intestinal lymphatic delivery
Drug delivery to the lymphatic system may be important in terms of the treatment with lymphatic involvement, such as tumor metastases and immunization. Especially, drug transport via the intestinal lymphatics ...
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Article
Rosin Nanoparticles as a Drug Delivery Carrier for the Controlled Release of Hydrocortisone
Hydrocortisone (HC)-loaded rosin nanoparticles were prepared by a dispersion and dialysis method without addition of surfactant. They were spherical: 167–332 nm diam. The drug was loaded approximately 50% of i...
