-
Article
Open AccessSilvestrol induces early autophagy and apoptosis in human melanoma cells
Silvestrol is a cyclopenta[b]benzofuran that was isolated from the fruits and twigs of Aglaia foveolata, a plant indigenous to Borneo in Southeast Asia. The purpose of the current study was to determine if inhibi...
-
Article
Sorbicillinoid analogs with cytotoxic and selective anti-Aspergillus activities from Scytalidium album
As part of an ongoing project to explore filamentous fungi for anticancer and antibiotic leads, 11 compounds were isolated and identified from an organic extract of the fungus Scytalidium album (MSX51631) using b...
-
Article
Investigation of Vietnamese plants for potential anticancer agents
Higher plants continue to afford humankind with many new drugs, for a variety of disease types. In this review, recent phytochemical and biological progress is presented for part of a collaborative multi-insti...
-
Article
Cytotoxic epipolythiodioxopiperazine alkaloids from filamentous fungi of the Bionectriaceae
Bioactivity-directed fractionation of the organic extracts of two filamentous fungi of the Bionectriaceae, strains MSX 64546 and MSX 59553 from the Mycosynthetix library, led to the isolation of a new dimeric ...
-
Article
Cytotoxic xanthone–anthraquinone heterodimers from an unidentified fungus of the order Hypocreales (MSX 17022)
Two new xanthone–anthraquinone heterodimers, acremoxanthone C (5) and acremoxanthone D (2), have been isolated from an extract of an unidentified fungus of the order Hypocreales (MSX 17022) by bioactivity-directe...
-
Protocol
Use of the Hollow Fiber Assay for the Discovery of Novel Anticancer Agents from Fungi
The hollow fiber assay (HFA) is a drug discovery tool to aid investigators in the prioritization of lead compounds identified by in vitro testing for further development in animal models of disease. In the HFA...
-
Article
Profound Effect of Plasma Protein Binding on the Polarized Transport of Furosemide and Verapamil in the Caco-2 Model
-
Article
In situ localization of prolactin receptor message in the mammary glands of pituitaryisografted mice
The receptors for prolactin (PRLR) are expressed in many tissues including the mammary gland, a classical target tissue for prolactin (PRL), but the cellular localization of expression of the PRLR gene in mamm...
-
Article
Stevioside biosynthesis by callus, root, shoot and rooted-shoot cultures in vitro
Leaf explants of Stevia rebaudiana Bertoni (Compositae), an herb which produces the sweet ent-kaurene glycoside stevioside, were cultured in Murashige and Skoog medium with vitamins, sucrose (30 g l−1), agar (0.9...
-
Chapter
Regulatory Negotiation: Lessons from Benzene
Recent efforts by the Occupational Safety and Health Administration (OSHA) to negotiate an agreement on a revised standard for occupational exposure to benzene represented an important initiative by the Agency...
