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Article
Antibacterial therapy in patients with malignancies
Patients with malignant disease may be predisposed to bacterial infections because of neoplastic disruption of normal tissue barriers, exogenous immunosuppressive therapy (drugs with or without radiation), and...
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Article
The Microbial Consequences of Antimediator Therapy for Sepsis
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Article
Immunocompromised Animals in Sepsis Research
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Chapter
Endotoxin scavengers as a therapeutic strategy for sepsis
Bacterial endotoxin remains an important therapeutic target for the treatment of serious infections from Gram-negative bacterial pathogens. Despite recent failures in past clinical trials with novel anti-endot...
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Article
New Potential Therapeutic Modalities: Antithrombin III
The role of the disordered coagulation in the pathogenesis of the microcirculatory failure that frequently accompanies sepsis has been clearly established in a multitude of preclinical animal systems. There is...
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Article
Immunoprophylaxis Against Bacterial Sepsis
Sepsis can be viewed as toxigenic illness resulting from the release of excess quantities of microbial-derived inflammatory mediators into the systemic circulation. Principal among these microbial mediators is...
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Chapter
Interleukin-11: Potential Therapeutic Activity in Systemic Inflammatory States
Interleukin-11 IL-11) is a multifunctional, immunoregulatory cytokine with several unique attributes that has therapeutic potential in a number of systemic inflammatory states. Like many other pleiotropic cyto...
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Article
The Genomic Era and 21st Century Medicine: Its Potential Impact in Sepsis Research
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Chapter
Vaccines Against Bacterial Endotoxins
The use of vaccines that induce antibodies to either highly conserved epitopes in the LPS core or to serotype-specific antigens (O-polysaccharide or CPS) remains a viable strategy for the prevention and/or tre...
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Chapter
Immunopathogenesis of Gram-Negative Shock
It has become evident that Gram-negative bacterial pathogens have evolved an elaborate array of virulence factors that contribute to the immunopathogenesis of systemic infection and septic shock. Microorganism...
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Article
Bench-to-bedside review: Toll-like receptors and their role in septic shock
The Toll-like receptors (TLRs) are essential transmembrane signaling receptors of the innate immune system that alert the host to the presence of a microbial invader. The recent discovery of the TLRs has rapid...
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Article
Quality of life effects of antithrombin III in sepsis survivors: results from the KyberSept trial [ISRCTN22931023]
Treatment of sepsis is aimed at increasing both the duration and quality of survival. A long-term focus on quality of life (QoL) in clinical trial evaluations of sepsis care should be a priority.
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Article
Bench-to-bedside review: Functional relationships between coagulation and the innate immune response and their respective roles in the pathogenesis of sepsis
The innate immune response system is designed to alert the host rapidly to the presence of an invasive microbial pathogen that has breached the integument of multicellular eukaryotic organisms. Microbial invas...
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Article
2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference
In 1991, the American College of Chest Physicians (ACCP) and the Society of Critical Care Medicine (SCCM) convened a "Consensus Conference," the goals of which were to "provide a conceptual and a practical fra...
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Article
Coagulation in sepsis
Coagulation abnormalities, ranging from a simple fall in platelet count to full-blown disseminated intravascular coagulation, are a common occurrence in critically ill patients and have been associated with i...
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Article
Role of Toll-Like Receptors in Infection and Immunity
The remarkable discovery of the Toll-like receptors (TLRs) over the past 5 years has opened up an entirely new era in the understanding of the molecular events that initiate the inflammatory response. These ty...
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Article
Coagulation abnormalities in critically ill patients
Many critically ill patients develop hemostatic abnormalities, ranging from isolated thrombocytopenia or prolonged global clotting tests to complex defects, such as disseminated intravascular coagulation. Ther...
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Article
Open AccessInhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infection
The receptor for advanced glycation end products (RAGE), a multi-ligand member of the immunoglobulin superfamily, contributes to acute and chronic disease processes, including sepsis.
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Article
Bench-to-bedside review: Quorum sensing and the role of cell-to-cell communication during invasive bacterial infection
Bacteria communicate extensively with each other and employ a communal approach to facilitate survival in hostile environments. A hierarchy of cell-to-cell signaling pathways regulates bacterial growth, metabo...
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Article
Open AccessA clinical evaluation committee assessment of recombinant human tissue factor pathway inhibitor (tifacogin) in patients with severe community-acquired pneumonia
The purpose of this analysis was to determine the potential efficacy of recombinant human tissue factor pathway inhibitor (tifacogin) in a subpopulation of patients with community-acquired pneumonia (CAP) from...
