De dokter en het geld
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How to manage coagulopathies in critically ill patients
Coagulopathy is a severe and frequent complication in critically ill patients, for which the pathogenesis and presentation may be variable depending on the underlying disease. Based on the dominant clinical ph...
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Inflammation, coagulation, and cellular injury in heat-induced shock
The number of heatstroke victims hit record numbers in 2022 as global warming continues. In heat-induced injuries, circulatory shock is the most severe and deadly complication. This review aims to examine the ...
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Open AccessNevertheless, the importance of coagulation abnormalities should be emphasized in international sepsis guidelines
It is generally accepted that a coagulation/fibrinolysis disorder is involved in the pathogenesis of sepsis, and the association of disseminated intravascular coagulation (DIC) and poor outcomes have been repo...
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Endothelial dysfunction and immunothrombosis as key pathogenic mechanisms in COVID-19
Coronavirus disease 2019 (COVID-19) is a clinical syndrome caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with severe disease show hyperactivation of the immune...
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Open AccessCOVID-19 coagulopathy: is it disseminated intravascular coagulation?
One of the significant complications of severe COVID-19 infections is a coagulopathy that seems to be related to the occurrence of venous and arterial thromboembolic disease. The coagulation changes mimic but ...
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Author Correction: Scalable and robust SARS-CoV-2 testing in an academic center
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Scalable and robust SARS-CoV-2 testing in an academic center
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Open AccessThe unique characteristics of COVID-19 coagulopathy
Thrombotic complications and coagulopathy frequently occur in COVID-19. However, the characteristics of COVID-19-associated coagulopathy (CAC) are distinct from those seen with bacterial sepsis-induced coagulo...
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Open AccessStrengths and weaknesses of the acute care systems in the United Kingdom and the Netherlands: what can we learn from each other?
The demand on Emergency Departments and acute medical services is increasing internationally, creating pressure on health systems and negatively influencing the quality of delivered care. Visible consequences ...
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Acquired Bleeding Disorders
There are several acquired defects in the coagulation system that may lead to bleeding. Most of these conditions can be detected by routinely available coagulation tests, such as the platelet count, prothrombi...
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Book
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Book
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Erratum behorend bij: ‘De dokter en het geld’
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6 De prijs van dure geneesmiddelen
Met de snel toenemende mogelijkheden voor betere behandeling van ziekten is het steeds meer de vraag of de maatschappij in staat en bereid is de stijgende kosten daarvan te dragen. Het debat spitst zich moment...
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16 Zogenaamde innovaties: de praktijk van de medische apparatuur- en hulpmiddelenindustrie
In het ziekenhuis van honderd jaar geleden stond nauwelijks apparatuur en werd heel beperkt gebruik gemaakt van meestal simpele hulpmiddelen zoals verband, een verlostang of een chirurgische scalpel. Ook in de...
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What do sepsis-induced coagulation test result abnormalities mean to intensivists?
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Open AccessManagement of bleeding in patients treated with direct oral anticoagulants
Recently, a new generation of direct-acting oral anticoagulants (DOACs) with a greater specificity towards activated coagulation factors was introduced based on encouraging results for efficacy and safety in c...
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Disseminated intravascular coagulation
Disseminated intravascular coagulation (DIC) is an acquired syndrome characterized by widespread intravascular activation of coagulation that can be caused by infectious insults (such as sepsis) and non-infect...
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What’s new in the diagnostic criteria of disseminated intravascular coagulation?
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Hemostatic abnormalities in critically ill patients
Hemostatic abnormalities frequently occur in critically ill patients and may vary from prolonged global clotting tests or isolated thrombocytopenia, to composite defects, such as consumption coagulopathies. Th...
