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Article
Induction and Impact of Anti-Drug Responses Elicited by a Human Recombinant Coagulation Factor FXaI16L in Preclinical Species
This paper presents a systemic investigation of ADA development and ADA impact of a human coagulation factor in nonclinical species during drug development and provides insights into potential implications in ...
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Article
A zymogen-like factor Xa variant corrects the coagulation defect in hemophilia
Factor Xa would be ideally suited to control unregulated bleeding were it not for its extremely short half-life and tendency to overactivate clotting mechanisms. Ivanciu et al. show that a longer lived but less a...
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Article
Open AccessInhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infection
The receptor for advanced glycation end products (RAGE), a multi-ligand member of the immunoglobulin superfamily, contributes to acute and chronic disease processes, including sepsis.
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Article
Open AccessMolecular Profile of Peripheral Blood Mononuclear Cells from Patients with Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic inflammatory arthritis. Currently, diagnosis of RA may take several weeks, and factors used to predict a poor prognosis are not always reliable. Gene expression in RA may...
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Article
Molecular cloning of a cDNA encoding human antihaemophilic factor
A complete copy of the mRNA sequences encoding human coagulation factor VIII:C has been cloned and expressed. The DNA sequence predicts a single chain precursor of 2,351 amino acids with a relative molecular m...
