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  1. Article

    Open Access

    Comprehensive functional profiling of long non-coding RNAs through a novel pan-cancer integration approach and modular analysis of their protein-coding gene association networks

    Long non-coding RNAs (lncRNAs) are emerging as crucial regulators of cellular processes in diseases such as cancer, although the functions of most remain poorly understood. To address this, here we apply a nov...

    Kevin Walters, Radmir Sarsenov, Wen Siong Too, Roseanna K. Hare… in BMC Genomics (2019)

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  2. No Access

    Article

    Physiological characterization of the high malic acid-producing Aspergillus oryzae strain 2103a-68

    Malic acid is a C4 dicarboxylic acid that is currently mainly used in the food and beverages industry as an acidulant. Because of the versatility of the group of C4 dicarboxylic acids, the chemical industry has a...

    Christoph Knuf, Intawat Nookaew, Ilse Remmers… in Applied Microbiology and Biotechnology (2014)

  3. No Access

    Protocol

    Designing RNAi Screens to Identify JAK/STAT Pathway Components

    The JAK/STAT signaling pathway has essential roles in multiple developmental processes, including stem cell maintenance, immune responses, and cellular proliferation. As a result, it has been extensively studi...

    Katherine H. Fisher, Stephen Brown, Martin P. Zeidler in JAK-STAT Signalling (2013)

  4. Article

    Open Access

    Advances in genome-wide RNAi cellular screens: a case study using the Drosophila JAK/STAT pathway

    Genome-scale RNA-interference (RNAi) screens are becoming ever more common gene discovery tools. However, whilst every screen identifies interacting genes, less attention has been given to how factors such as ...

    Katherine H Fisher, Victoria M Wright, Amy Taylor, Martin P Zeidler… in BMC Genomics (2012)

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  5. No Access

    Article

    Ethylene receptor expression is regulated during fruit ripening, flower senescence and abscission

    Using theArabidopsis ethylene receptorETR1 as a probe, we have isolated a tomato homologue (tETR) from a ripening cDNA library. The predicted amino acid sequence is 70% identical toETR1 and homologous to a variet...

    Sharon Payton, Rupert G. Fray, Stephen Brown, Don Grierson in Plant Molecular Biology (1996)

  6. No Access

    Chapter

    Isolation of Coding Sequence from Cosmids and YACs by Exon Amplification

    Exon amplification is an increasingly popular approach to the identification of transcribed sequences and complements other strategies to rapidly isolate coding sequence. The following chapter describes applic...

    Michael North, Fernando Gibson, Stephen Brown… in Identification of Transcribed Sequences (1994)

  7. No Access

    Article

    Spatial variation in larval concentrations as a cause of spatial variation in settlement for the barnacle, Balanus glandula

    Settlement rates of the high intertidal barnacle, Balanus glandula, were monitored at three sites in the rocky intertidal zone in Central California simultaneously with measurements of larval concentrations in th...

    Steven Gaines, Stephen Brown, Jonathan Roughgarden in Oecologia (1985)