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Open AccessShort tandem repeat sequences in the Mycoplasma genitaliumgenome and their use in a multilocus genoty** system
Several methods have been reported for strain ty** of Mycoplasma genitalium. The value of these methods has never been comparatively assessed. The aims of this study were: 1) to identify new potential genetic m...
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Article
Open AccessPrescribing patterns of asthma controller therapy for children in UK primary care: a cross-sectional observational study
Asthma management guidelines recommend a stepwise approach to instituting and adjusting anti-inflammatory controller therapy for children with asthma. The objective of this retrospective observational study wa...
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Article
Open AccessPhysical activity and depressive symptoms in adolescents: a prospective study
The frequency of mental illness amongst adolescents and its potential long-term consequences make it an important topic to research in relation to risk and protective factors. Research on the relationship betw...
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Open AccessThe OPERA trial: protocol for a randomised trial of an exercise intervention for older people in residential and nursing accommodation
Depression is common in residents of Residential and Nursing homes (RNHs). It is usually undetected and often undertreated. Depression is associated with poor outcomes including increased morbidity and mortali...
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Article
Open AccessReengineering the clinical research enterprise to involve more community clinicians
The National Institutes of Health has called for expansion of practice-based research to improve the clinical research enterprise.
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Open AccessBridging the gap between basic science and clinical practice: a role for community clinicians
Translating the extraordinary scientific and technological advances occurring in medical research laboratories into care for patients in communities throughout the country has been a major challenge. One contr...
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Open AccessBridging the gap between basic science and clinical practice: The role of organizations in addressing clinician barriers
New National Institutes of Health policies call for expansion of practice-based research to improve the clinical research enterprise and facilitate dissemination of evidence-based medicine.
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Article
Special Issue Introduction: Creativity and Creative Work in Contemporary Working Contexts
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Open AccessReporting participation rates in studies of non-pharmacological interventions for patients with chronic obstructive pulmonary disease: a systematic review
Pulmonary rehabilitation (PR) and self-management (SM) support programmes are effective in the management of patients with chronic obstructive pulmonary disease (COPD), but these interventions are not widely i...
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Open AccessSelf-Management education for adults with poorly controlled epILEpsy (SMILE (UK)): a randomised controlled trial protocol
Teaching people with epilepsy to identify and manage seizure triggers, implement strategies to remember to take antiepileptic drugs, implement precautions to minimize risks during seizures, tell others what to...
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Open AccessHow do physicians decide to treat: an empirical evaluation of the threshold model
According to the threshold model, when faced with a decision under diagnostic uncertainty, physicians should administer treatment if the probability of disease is above a specified threshold and withhold treat...
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Open AccessSelf-management education for adults with poorly controlled epilepsy (SMILE (UK)): statistical, economic and qualitative analysis plan for a randomised controlled trial
There is a need to test the effectiveness of new educational interventions for people with poorly controlled epilepsy. The SMILE (self-management education for adults with poorly controlled epilepsy) trial eva...
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Open AccessA user needs assessment to inform health information exchange design and implementation
Important barriers for widespread use of health information exchange (HIE) are usability and interface issues. However, most HIEs are implemented without performing a needs assessment with the end users, healt...
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Open AccessHow best to design a clinical trial that is relevant to practice? Applying PRECIS-2, a trial design tool, to primary care trials
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Open AccessCharacteristics associated with quality of life among people with drug-resistant epilepsy
Quality of Life (QoL) is the preferred outcome in non-pharmacological trials, but there is little UK population evidence of QoL in epilepsy. In advance of evaluating an epilepsy self-management course we aimed...
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Creative Aspiration and the Betrayal of Promise? The Experience of New Creative Workers
The promise of ‘doing what you love’ continues to attract new aspirants to creative work, yet most creative industries are so characterised by low investment, shifting foci and ongoing technological innovation...
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New Pathways into Creative Work?
The experience of aspiring creative workers contrasts sharply with Paul Willis’s classic account of entry to working life from almost half a century ago, in his book, Learning to labour (1977). Creative work enta...
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Open AccessImpulsivity is a heritable trait in rodents and associated with a novel quantitative trait locus on chromosome 1
Impulsivity describes the tendency to act prematurely without appropriate foresight and is symptomatic of a number of neuropsychiatric disorders. Although a number of genes for impulsivity have been identified...
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Open AccessDevelo** a complex intervention whilst considering implementation: the TANDEM (Tailored intervention for ANxiety and DEpression Management) intervention for patients with chronic obstructive pulmonary disease (COPD)
Guidelines now call for a thorough and comprehensive description of the development of healthcare interventions to aid evaluation and understanding of the processes of change. This was the primary aim of this ...
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Open AccessThe TANDEM trial: protocol for the process evaluation of a randomised trial of a complex intervention for anxiety and/or depression in people living with chronic obstructive pulmonary disease (COPD)
TANDEM is a randomised controlled trial of a complex healthcare intervention to improve the psychological and physical health of people living with chronic obstructive pulmonary disease (COPD) and anxiety and/...
