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Open AccessMutant GGGGCC RNA prevents YY1 from binding to Fuzzy promoter which stimulates Wnt/β-catenin pathway in C9ALS/FTD
The GGGGCC hexanucleotide repeat expansion mutation in the chromosome 9 open reading frame 72 (C9orf72) gene is a major genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia (C9ALS/FTD). In t...
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Open AccessIMP2ART: development of a multi-level programme theory integrating the COM-B model and the iPARIHS framework, to enhance implementation of supported self-management of asthma in primary care
Supported asthma self-management, incorporating an asthma action plan and annual clinical review, has been recommended by UK/global guidelines for over three decades. However, implementation remains poor, as o...
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Open AccessThe TANDEM trial: protocol for the process evaluation of a randomised trial of a complex intervention for anxiety and/or depression in people living with chronic obstructive pulmonary disease (COPD)
TANDEM is a randomised controlled trial of a complex healthcare intervention to improve the psychological and physical health of people living with chronic obstructive pulmonary disease (COPD) and anxiety and/...
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Open AccessDevelo** a complex intervention whilst considering implementation: the TANDEM (Tailored intervention for ANxiety and DEpression Management) intervention for patients with chronic obstructive pulmonary disease (COPD)
Guidelines now call for a thorough and comprehensive description of the development of healthcare interventions to aid evaluation and understanding of the processes of change. This was the primary aim of this ...
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Open AccessImpulsivity is a heritable trait in rodents and associated with a novel quantitative trait locus on chromosome 1
Impulsivity describes the tendency to act prematurely without appropriate foresight and is symptomatic of a number of neuropsychiatric disorders. Although a number of genes for impulsivity have been identified...
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A toxicity-based analysis of Canada’s National Pollutant Release Inventory (NPRI): a case study in Nova Scotia
After the success of the Toxics Release Inventory (TRI) in the United States (US), Canada created the National Pollutant Release Inventory (NPRI). Both NPRI and TRI focus on public opinion to coerce facilities...
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Creative Aspiration and the Betrayal of Promise? The Experience of New Creative Workers
The promise of ‘doing what you love’ continues to attract new aspirants to creative work, yet most creative industries are so characterised by low investment, shifting foci and ongoing technological innovation...
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New Pathways into Creative Work?
The experience of aspiring creative workers contrasts sharply with Paul Willis’s classic account of entry to working life from almost half a century ago, in his book, Learning to labour (1977). Creative work enta...
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Isolation and characterization of bacteriophage NTR1 infectious for Nocardia transvalensis and other Nocardia species
We describe here the isolation and characterization of the bacteriophage, NTR1 from activated sludge. This phage is lytic for Nocardia transvalensis, Nocardia brasiliensis and Nocardia farcinica. NTR1 phage has a...
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Collection Introduction: The ‘New Normal’ of Working Lives
Lauren Berlant (2011) has written of the need to understand the problem of living contemporary lives, including the ‘new normal’ and ‘new ordinary’ (p. 261). This collection investigates the new normal of work...
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Beyond Work? New Expectations and Aspirations
This chapter considers the extent to which new aspirations and expectations have become attached to work, and the possible emergence of new norms linked to the models of the creative worker and entrepreneur. T...
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Open AccessCharacteristics associated with quality of life among people with drug-resistant epilepsy
Quality of Life (QoL) is the preferred outcome in non-pharmacological trials, but there is little UK population evidence of QoL in epilepsy. In advance of evaluating an epilepsy self-management course we aimed...
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Psychosocial Research
The relatively new area of psychosocial studies has developed in part as a critique of psychology and a response to its supposed deficiencies. This chapter reviews the relationship between the psychosocial and...
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Open AccessHow best to design a clinical trial that is relevant to practice? Applying PRECIS-2, a trial design tool, to primary care trials
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Open AccessA user needs assessment to inform health information exchange design and implementation
Important barriers for widespread use of health information exchange (HIE) are usability and interface issues. However, most HIEs are implemented without performing a needs assessment with the end users, healt...
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Open AccessSelf-management education for adults with poorly controlled epilepsy (SMILE (UK)): statistical, economic and qualitative analysis plan for a randomised controlled trial
There is a need to test the effectiveness of new educational interventions for people with poorly controlled epilepsy. The SMILE (self-management education for adults with poorly controlled epilepsy) trial eva...
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Open AccessHow do physicians decide to treat: an empirical evaluation of the threshold model
According to the threshold model, when faced with a decision under diagnostic uncertainty, physicians should administer treatment if the probability of disease is above a specified threshold and withhold treat...
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Open AccessSelf-Management education for adults with poorly controlled epILEpsy (SMILE (UK)): a randomised controlled trial protocol
Teaching people with epilepsy to identify and manage seizure triggers, implement strategies to remember to take antiepileptic drugs, implement precautions to minimize risks during seizures, tell others what to...
