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Protamine is an inhibitor of angiogenesis

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Abstract

Protamine is shown to be a specific inhibitor of angiogenesis. The compound inhibits the capillary proliferation observed in embryogenesis, inflammation, certain immune reactions and the growth of solid tumours.

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Authors and Affiliations

  1. Department of Surgery, Children's Hospital Medical Center and the Departments of Anatomy and Surgery, Harvard Medical School, Boston, Massachusetts, 02115, USA

    Stephanie Taylor & Judah Folkman

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  1. Stephanie Taylor
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  2. Judah Folkman
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Taylor, S., Folkman, J. Protamine is an inhibitor of angiogenesis. Nature 297, 307–312 (1982). https://doi.org/10.1038/297307a0

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