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  1. Article

    Open Access

    Partial freezing of rat livers extends preservation time by 5-fold

    The limited preservation duration of organs has contributed to the shortage of organs for transplantation. Recently, a tripling of the storage duration was achieved with supercooling, which relies on temperatu...

    Shannon N. Tessier, Reinier J. de Vries, Casie A. Pendexter in Nature Communications (2022)

  2. No Access

    Article

    Subzero non-frozen preservation of human livers in the supercooled state

    Preservation of human organs at subzero temperatures has been an elusive goal for decades. The major complication hindering successful subzero preservation is the formation of ice at temperatures below freezin...

    Reinier J. de Vries, Shannon N. Tessier, Peony D. Banik, Sonal Nagpal in Nature Protocols (2020)

  3. Article

    Open Access

    Cell release during perfusion reflects cold ischemic injury in rat livers

    The global shortage of donor organs has made it crucial to deeply understand and better predict donor liver viability. However, biomarkers that effectively assess viability of marginal grafts for organ transpl...

    Reinier J. de Vries, Casie A. Pendexter, Stephanie E. J. Cronin in Scientific Reports (2020)

  4. No Access

    Article

    Supercooling extends preservation time of human livers

    The inability to preserve vascular organs beyond several hours contributes to the scarcity of organs for transplantation1,2. Standard hypothermic preservation at +4 °C (refs. 1,3) limits liver preservation to les...

    Reinier J. de Vries, Shannon N. Tessier, Peony D. Banik in Nature Biotechnology (2019)