-
Article
Open AccessPublisher Correction: Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly
The original version of this Article contained an error in the spelling of the author Jule Müller, which was incorrectly given as Julia Müller. Additionally, in Fig. 4a, the blue-red colour scale for fold chan...
-
Article
Open AccessTranscriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly
Disease epidemiology during ageing shows a transition from cancer to degenerative chronic disorders as dominant contributors to mortality in the old. Nevertheless, it has remained unclear to what extent molecu...
-
Article
Open AccessConserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence
Cellular senescence is induced either internally, for example by replication exhaustion and cell division, or externally, for example by irradiation. In both cases, cellular damages accumulate which, if not su...
-
Article
Open AccessBranched-chain amino acid catabolism is a conserved regulator of physiological ageing
Ageing has been defined as a global decline in physiological function depending on both environmental and genetic factors. Here we identify gene transcripts that are similarly regulated during physiological ag...
-
Article
Open AccessHormetic effect of rotenone in primary human fibroblasts
Rotenone inhibits the electron transfer from complex I to ubiquinone, in this way interfering with the electron transport chain in mitochondria. This chain of events induces increased levels of intracellular r...
-
Article
Open AccessD-Glucosamine supplementation extends life span of nematodes and of ageing mice
D-Glucosamine (GlcN) is a freely available and commonly used dietary supplement potentially promoting cartilage health in humans, which also acts as an inhibitor of glycolysis. Here we show that GlcN, independe.....
-
Article
Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide
Nematodes define a new role for sirtuins in lifespan extension, in which the sirtuin product nicotinamide is converted to a substrate for aldehyde oxidase; turnover of this enzyme generates hydrogen peroxide, ...
-
Article
Open AccessThe transcript catalogue of the short-lived fish Nothobranchius furzeriprovides insights into age-dependent changes of mRNA levels
The African annual fish Nothobranchius furzeri has over recent years been established as a model species for ageing-related studies. This is mainly based on its exceptionally short lifespan and the presence of ty...
-
Article
Open AccessEffect of L-carnitine on the hepatic transcript profile in piglets as animal model
Carnitine has attracted scientific interest due to several health-related effects, like protection against neurodegeneration, mitochondrial decay, and oxidative stress as well as improvement of glucose toleran...
-
Article
Open AccessComparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi
Millions of humans and animals suffer from superficial infections caused by a group of highly specialized filamentous fungi, the dermatophytes, which exclusively infect keratinized host structures. To provide ...
-
Chapter and Conference Paper
Towards Automatic Pathway Generation from Biological Full-Text Publications
We introduce an approach to the automatic generation of biological pathway diagrams from scientific literature. It is composed of the automatic extraction of single interaction relations which are typically fo...
-
Chapter and Conference Paper
Hierarchical Master-Worker Skeletons
Master-worker systems are a well-known and often applicable scheme for the parallel evaluation of a pool of tasks, a work pool. The system consists of a master process managing a set of worker processes. After an...
-
Chapter and Conference Paper
Preprocessing Eden with Template Haskell
Extending a programming language by new language constructs often implies extending its compiler by additional machinery. To reduce the complex interweaving of compiler and extension implementations we present...
-
Chapter and Conference Paper
High-Level Process Control in Eden
High-level control of parallel process behaviour simplifies the development of parallel software substantially by freeing the programmer from low-level process management and coordination details. The latter a...
-
Chapter
Parallelism Abstractions in Eden
Two important abstractions have contributed to create a reliable programming methodology for industrial-strength programs These are functional abstraction (which has received different names in programming lan...
-
Chapter and Conference Paper
Functional Vs Object-Oriented Distributed Languages
Conventional distributed programming languages require the programmer to explicitly specify many aspects of distributed coordination, including resource location, task placement, communication and synchronisat...
-
Chapter and Conference Paper
Implementation Skeletons in Eden: Low-Effort Parallel Programming
Algorithmic skeletons define general patterns of computation which are useful for exposing the computational structure of a program. Being general structures they qualify as a target for parallelisation, which is...
