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Article
Open AccessProcalcitonin serum levels in tertian malaria
Procalcitonin (PCT) is closely correlated with parasite burden and clinical outcome in falciparum malaria. The role of PCT in tertian malaria has not previously been investigated.
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Article
PKCμ prevents CD95-mediated apoptosis and enhances proliferation in pancreatic tumour cells
Loss of growth control and a marked resistance to apoptosis are considered major mechanisms driving tumour progression. Protein kinases C (PKC) have been shown to be important in the regulation of proliferatio...
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Article
Open AccessReduced cardiac output in imported Plasmodium falciparum malaria
Volume substitution remains subject of controversy in the light of effusions and oedema potentially complicating this highly febrile disease. Understanding the role of myocardial and circulatory function appea...
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Article
Characterization of Enterobacter cloacae Pneumonia: A Single-Center Retrospective Analysis
Enterobacter cloacae (E. cloacae) is a Gram-negative rod commonly found on intensive care units (ICU) causing severe infections with high mortality. Specific characteristics of E. cloa...
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Article
Open AccessPost-treatment haemolysis in severe imported malaria after intravenous artesunate: case report of three patients with hyperparasitaemia
Parenteral artesunate has been shown to be a superior treatment option compared to parenteral quinine in adults and children with severe malaria. Little evidence, however, is available on long-term safety. Rec...
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Article
Open AccessArtesunate versus quinine in the treatment of severe imported malaria: comparative analysis of adverse events focussing on delayed haemolysis
Severe malaria is a potentially life-threatening infectious disease. It has been conclusively shown that artesunate compared to quinine is superior in antiparasitic efficacy and in lowering mortality showing a...
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Article
Open AccessSafety and efficacy of protease inhibitor based combination therapy in a single-center “real-life” cohort of 110 patients with chronic hepatitis C genotype 1 infection
The combination of boceprevir or telaprevir with peginterferon-alfa and ribavirin for the treatment of patients infected with HCV genotype 1 has led to significantly increased rates of sustained virological re...
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Article
Open AccessGerman cohort of HCV mono-infected and HCV/HIV co-infected patients reveals relative under-treatment of co-infected patients
Current German and European HIV guidelines recommend early evaluation of HCV treatment in all HIV/HCV co-infected patients. However, there are still considerable barriers to initiate HCV therapy in everyday cl...
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Living Reference Work Entry In depth
Infektionen des zentralen Nervensystems
Infektionserkrankungen des zentralen Nervensystems (ZNS) werden von unterschiedlichen bakteriellen, viralen, parasitären Erregern und Pilzen hervorgerufen. Sowohl das Erregerspektrum als auch die Symptomatik i...
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Article
Isolation in patients with Ebola virus disease
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Article
Unique human immune signature of Ebola virus disease in Guinea
Fatal Ebola virus disease is characterized by a high proportion of CD4+ and CD8+ T cells expressing the inhibitory molecules CTLA-4 and PD-1, correlating with high virus load; individuals who survive the infectio...
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Article
High proportion of HIV late presenters at an academic tertiary care center in northern Germany confirms the results of several cohorts in Germany: time to put better HIV screening efforts on the national agenda?
165 treatment-naive patients who first presented at the infectious disease clinic of the University Medical Center Hamburg-Eppendorf from 2009 to 2011 were retrospectively analyzed with emphasis on patients wi...
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Article
Open AccessScreening and contact precautions – A survey on infection control measures for multidrug-resistant bacteria in German university hospitals
To assess the scope of infection control measures for multidrug-resistant bacteria in high-risk settings, a survey among university hospitals was conducted. Fourteen professionals from 8 sites participated. Re...
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Article
Epidemiology, clinical and laboratory features of 24 consecutive cases of leptospirosis at a German infectious disease center
To determine epidemiological, clinical and laboratory characteristics of leptospirosis, 24 consecutive patients diagnosed with the infection between 2011 and 2017 at the University Medical Center Hamburg-Eppen...
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Article
Management der saisonalen Influenza 2017/2018: Erfahrungen an einem deutschen Universitätsklinikum
Es gibt nur wenige strukturierte klinische Erfahrungsberichte zum stationären Management einer saisonalen Influenzaepidemie.
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Article
Open AccessImmediate versus deferred antiretroviral therapy in HIV-infected patients presenting with acute AIDS-defining events (toxoplasmosis, Pneumocystis jirovecii-pneumonia): a prospective, randomized, open-label multicenter study (IDEAL-study)
To evaluate clinical outcomes after either immediate or deferred initiation of antiretroviral therapy in HIV-1-infected patients, presenting late with pneumocystis pneumonia (PCP) or toxoplasma encephalitis (TE).
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Chapter
Gastroenteritiden und Peritonitis
Gastroenteritiden und Enterokolitiden sind Erkrankungen der Schleimhäute des Magen-Darm-Trakts, die durch Mikroorganismen oder deren Toxine verursacht werden. Sie führen klinisch zu Übelkeit, Erbrechen, Durchf...
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Article
Open AccessWound infection with Vibrio harveyi following a traumatic leg amputation after a motorboat propeller injury in Mallorca, Spain: a case report and review of literature
Vibrio spp. are aquatic bacteria that are ubiquitous in warm estuarine and marine environments, of which 12 species are currently known to cause infections in humans. So far, only five human infections with V. ha...
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Chapter
Parasitäre Infektionen in der AVC – die Echinokokkose
Die Echinokokkosen des Menschen sind parasitäre Infektionen mit meist primärem Leberbefall. Es existiert die weltweit verbreitete zystische Echinokokkose (Hundebandwurm) sowie die alveoläre Echinokokkose, ein ...
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Chapter
Enzephalitis
Virale Infektionen des Nervensystems sind häufig ein neurologischer Notfall und differenzialdiagnostisch anspruchsvoll und können durch eine Vielzahl von Erregern ausgelöst werden. Die rasche Diagnose und ansc...
