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Open AccessConcordance between MITS and conventional autopsies for pathological and virological diagnoses
In pandemics or to further study highly contagious infectious diseases, new strategies are needed for the collection of post-mortem tissue samples to identify the pathogen as well as its morphological impact. ...
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Article
Open AccessAdaptation and validation of a quantitative vanA/vanB DNA screening assay on a high-throughput PCR system
Vancomycin resistant enterococci (VRE) are a leading cause of ICU-acquired bloodstream infections in Europe. The bacterial load in enteral colonization may be associated with a higher probability of transmissi...
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Open AccessHigh burden of RSV and influenza in patients presenting with suspected pneumonia in the emergency room of a German tertiary hospital in fall of 2022
Bacterial pneumonia, a major cause of respiratory tract infections (RTI), can be challenging to diagnose and to treat adequately, especially when seasonal viral pathogens co-circulate. The aim of this study wa...
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Open AccessTecovirimat for the treatment of severe Mpox in Germany
In May 2022, a multi-national mpox outbreak was reported in several non-endemic countries. The only licensed treatment for mpox in the European Union is the orally available small molecule tecovirimat, which in O...
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Open AccessVagus nerve inflammation contributes to dysautonomia in COVID-19
Dysautonomia has substantially impacted acute COVID-19 severity as well as symptom burden after recovery from COVID-19 (long COVID), yet the underlying causes remain unknown. Here, we hypothesized that vagus n...
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Open AccessPilot study in Hamburg on the prevalence of SARS-CoV-2 infections and pandemic survey in the German funeral industry
Funeral home and crematorium workers are an important occupational group in the corona crisis. The occupational setting led to concerns about an increased risk of infection with SARS-CoV-2. The seroprevalence ...
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Open AccessLong-Term Antibody Response to SARS-CoV-2 in Children
Almost 2 years into the pandemic and with vaccination of children significantly lagging behind adults, long-term pediatric humoral immune responses to SARS-CoV-2 are understudied. The C19.CHILD Hamburg (COVID...
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Open AccessMolecular consequences of SARS-CoV-2 liver tropism
Extrapulmonary manifestations of COVID-19 have gained attention due to their links to clinical outcomes and their potential long-term sequelae1. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) displa...
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Open AccessDying of VOC-202012/01 — multimodal investigations in a death case of the SARS-CoV-2 variant
The current pandemic with Severe acute respiratory syndrome-coronavirus-2 has been taking on new dynamics since the emergence of new variants last fall, some of them spreading more rapidly. Many countries current...
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Open AccessMulticenter Evaluation of a Fully Automated High-Throughput SARS-CoV-2 Antigen Immunoassay
Molecular testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to suffer from delays and shortages. Antigen tests have recently emerged as a viable alternative to detect patients ...
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Open AccessMultiorgan tropism of SARS-CoV-2 lineage B.1.1.7
Due to the development of novel functionalities, distinct SARS-CoV-2 variants such as B.1.1.7 fuel the current pandemic. B.1.1.7 is not only more transmissible, but may also cause an increased mortality compar...
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Open AccessSARS-CoV‑2-Zufallsentdeckungen bei Hamburger Todesfällen: ein epidemiologisches Monitoring während des dynamischen Infektionsgeschehens im Frühjahr 2020
Im Rahmen der COVID-19-Pandemie sind Inzidenz und Mortalität entscheidende Determinanten, um Ausbreitungsdynamik und Gefahrenpotenzial zu beurteilen. Untersucht wird, ob ein systematisches mikrobiologisches Mo...
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Open AccessProspective postmortem evaluation of 735 consecutive SARS-CoV-2-associated death cases
Coronavirus disease 19 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic with significant mortality. Accurate information on the specific circumst...
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Open AccessThe handling of SARS-CoV-2 associated deaths - infectivity of the body
The body of a deceased with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is considered infectious. In this study, we present the results of infectivity testing of the body and testin...
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Open AccessInnate immunity in hepatitis B and D virus infection: consequences for viral persistence, inflammation, and T cell recognition
Chronic infections with human hepatitis viruses continue to be a major health burden worldwide. Despite the availability of an effective prophylactic vaccine against the hepatitis B virus (HBV) and of antivira...
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Open AccessPerformance of the BD Phoenix CPO detect assay for detection and classification of carbapenemase-producing organisms
Increasing worldwide, prevalence of carbapenem-resistant gram-negative bacteria demands urgent a need for rapid detection and accurate identification of carbapenemases. The BD Phoenix CPO detect (PCD) assay po...
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Open AccessSevere liver dysfunction complicating course of COVID-19 in the critically ill: multifactorial cause or direct viral effect?
SARS-CoV-2 caused a pandemic and global threat for human health. Presence of liver injury was commonly reported in patients with coronavirus disease 2019 (COVID-19). However, reports on severe liver dysfunctio...
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Open AccessComparison of clinical characteristics and disease outcome of COVID-19 and seasonal influenza
While several studies have described the clinical course of patients with coronavirus disease 2019 (COVID-19), direct comparisons with patients with seasonal influenza are scarce. We compared 166 patients with...
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Open AccessControl of SARS-CoV-2 infection in rituximab-treated neuroimmunological patients
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Open AccessAntibiotic sensitivity in correlation to the origin of secondary peritonitis: a single center analysis
Despite improvements in diagnosis, intensive-care medicine and surgical technique, the mortality of patients with secondary peritonitis is still high. Early and aggressive empiric antibiotic treatment has stro...
