9 Result(s)
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Stanislas Grassin-Delyle
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Article
Combination of real-time and hyphenated mass spectrometry for improved characterisation of exhaled breath biomarkers in clinical research
Exhaled breath volatilomics is a powerful non-invasive tool for biomarker discovery in medical applications, but compound annotation is essential for pathophysiological insights and technology transfer. This s...
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Article
Drugs Targeting Cough Receptors: New Therapeutic Options in Refractory or Unexplained Chronic Cough
Refractory chronic cough is a disabling disease with very limited therapeutic options. A better understanding of cough pathophysiology has led to the development of emerging drugs targeting cough receptors. Re...
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Article
Detection and quantification of 12 anabolic steroids and analogs in human whole blood and 20 in hair using LC-HRMS/MS: application to real cases
We developed and validated a method to detect and quantify 12 anabolic steroids in blood (androstenedione, dihydrotestosterone, boldenone, epitestosterone, mesterolone, methandienone, nandrolone, stanozolol, n...
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Open AccessHuman lung and monocyte-derived macrophages differ with regard to the effects of β2-adrenoceptor agonists on cytokine release
β2-adrenoceptor agonists have been shown to reduce the lipopolysaccharide (LPS)-induced cytokine release by human monocyte-derived macrophages (MDMs). We compare the expression of β2-adrenoceptors and the inhibit...
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Open AccessIn smokers, Sonic hedgehog modulates pulmonary endothelial function through vascular endothelial growth factor
Tobacco-induced pulmonary vascular disease is partly driven by endothelial dysfunction. The Sonic hedgehog (SHH) pathway is involved in vascular physiology. We sought to establish whether the SHH pathway has a...
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Open AccessThe impact of low-frequency, low-force cyclic stretching of human bronchi on airway responsiveness
In vivo, the airways are constantly subjected to oscillatory strain (due to tidal breathing during spontaneous respiration) and (in the event of mechanical ventilation) positive pressure. This exposure is espe...
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Open AccessThe expression and relaxant effect of bitter taste receptors in human bronchi
Bitter-taste receptors (TAS2Rs) have recently been involved in the relaxation of mouse and guinea pig airways, and increased expression of TAS2Rs was shown in blood leucocytes from asthmatic children. We sough...
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Open AccessAirway response to acute mechanical stress in a human bronchial model of stretch
Lung inflation may have deleterious effects on the alveoli during mechanical ventilation. However, the consequences of stretch during excessive lung inflation on basal tone and responsiveness of human bronchi ...
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Article
Open AccessExpression and function of human hemokinin-1 in human and guinea pig airways
Human hemokinin-1 (hHK-1) and endokinins are peptides of the tachykinin family encoded by the TAC4 gene. TAC4 and hHK-1 expression as well as effects of hHK-1 in the lung and airways remain however unknown and we...
