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  1. No Access

    Article

    Drugs Targeting Cough Receptors: New Therapeutic Options in Refractory or Unexplained Chronic Cough

    Refractory chronic cough is a disabling disease with very limited therapeutic options. A better understanding of cough pathophysiology has led to the development of emerging drugs targeting cough receptors. Re...

    Laurent Guilleminault, Stanislas Grassin-Delyle, Stuart B. Mazzone in Drugs (2024)

  2. Article

    Efficacy and Safety of Eliapixant in Refractory Chronic Cough: The Randomized, Placebo-Controlled Phase 2b PAGANINI Study

    The PAGANINI study evaluated the efficacy and safety of the selective P2X3 antagonist eliapixant in patients with refractory chronic cough (RCC).

    Peter V. Dicpinigaitis, Alyn H. Morice, Jaclyn A. Smith, Mandel R. Sher… in Lung (2023)

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    Article

    Combining Anti-IgE Monoclonal Antibodies and Oral Immunotherapy for the Treatment of Food Allergy

    Immunoglobulin E (IgE)-mediated food allergy is a real public health problem worldwide. The prevalence of food allergy is particularly high in children. Patients with food allergy experience high morbidity wit...

    Laurent Guilleminault, Marine Michelet… in Clinical Reviews in Allergy & Immunology (2022)

  4. Article

    Open Access

    Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice

    Allergic asthma is characterized by elevated levels of IgE antibodies, type 2 cytokines such as interleukin-4 (IL-4) and IL-13, airway hyperresponsiveness (AHR), mucus hypersecretion and eosinophilia. Approved...

    Eva Conde, Romain Bertrand, Bianca Balbino, Jonathan Bonnefoy… in Nature Communications (2021)

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    Article

    Obesity Predicts Treatment Response to Proton Pump Inhibitor Therapy in Patients with Chronic Cough

    Chronic cough management is challenging as this condition is often associated with multiple comorbidities, requiring a multidisciplinary diagnostic approach. Little is known about the characteristics of obese ...

    Mathilde Descazeaux, Danièle Brouquières, Alain Didier, Marianne Lescouzères… in Lung (2020)

  6. No Access

    Article

    Asthma and Hypogammaglobulinemia: an Asthma Phenotype with Low Type 2 Inflammation

    Little is known about hypogammaglobulinemia (HGG) in asthma patients. No data are available on the characteristics of adult patients with asthma and HGG.

    Clairelyne Dupin, Sylvain Marchand-Adam, Olivier Favelle… in Journal of Clinical Immunology (2016)

  7. No Access

    Article

    Pharmacokinetics of Colistin Methansulphonate (CMS) and Colistin after CMS Nebulisation in Baboon Monkeys

    The objective of this study was to compare two different nebulizers: Eflow rapid® and Pari LC star® by scintigraphy and PK modeling to simulate epithelial lining fluid concentrations from measured plasma conce...

    Sandrine Marchand, Salim Bouchene, Michèle de Monte… in Pharmaceutical Research (2015)

  8. No Access

    Article

    The Airways, a Novel Route for Delivering Monoclonal Antibodies to Treat Lung Tumors

    Lung cancer is the leading cause of cancer-related death worldwide. The efficacy of current systemic treatments is limited, with major side effects and only modest survival improvements. Aerosols routinely use...

    Agnès Maillet, Laurent Guilleminault, Etienne Lemarié… in Pharmaceutical Research (2011)