16 Result(s)
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Soumyaroop Bhattacharya
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Article
Open AccessThe effect of air pollution on the transcriptomics of the immune response to respiratory infection
Combustion related particulate matter air pollution (PM) is associated with an increased risk of respiratory infections in adults. The exact mechanism underlying this association has not been determined. We hy...
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Article
CX3CR1 as a respiratory syncytial virus receptor in pediatric human lung
Data on the host factors that contribute to infection of young children by respiratory syncytial virus (RSV) are limited. The human chemokine receptor, CX3CR1, has recently been implicated as an RSV receptor. ...
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Article
A novel in vitro model of primary human pediatric lung epithelial cells
Current in vitro human lung epithelial cell models derived from adult tissues may not accurately represent all attributes that define homeostatic and disease mechanisms relevant to the pediatric lung.
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Article
Open AccessAuthor Correction: Transcriptional Regulation on Aneuploid Chromosomes in Diverse Candida albicans Mutants
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
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Article
Open AccessExome sequencing identifies gene variants and networks associated with extreme respiratory outcomes following preterm birth
Previous studies have identified genetic variants associated with bronchopulmonary dysplasia (BPD) in extremely preterm infants. However, findings with genome-wide significance have been rare, and not replicat...
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Article
Open AccessTranscriptional Regulation on Aneuploid Chromosomes in Diverse Candida albicans Mutants
Candida albicans is a diploid fungus and a predominant opportunistic human pathogen. Notably, C. albicans employs reversible chromosomal aneuploidies as a means of survival in adverse environments. We previously ...
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Article
Open AccessTranscriptomic Biomarkers to Discriminate Bacterial from Nonbacterial Infection in Adults Hospitalized with Respiratory Illness
Lower respiratory tract infection (LRTI) commonly causes hospitalization in adults. Because bacterial diagnostic tests are not accurate, antibiotics are frequently prescribed. Peripheral blood gene expression ...
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Article
Open AccessMicroRNA expression profiling defines the impact of electronic cigarettes on human airway epithelial cells
While all forms of tobacco exposure have negative health effects, the significance of exposure to electronic cigarettes (eCig) is not fully understood. Here, we studied the global effects of eCig on the micro ...
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Article
Open AccessThe Healthy Infant Nasal Transcriptome: A Benchmark Study
Responses by resident cells are likely to play a key role in determining the severity of respiratory disease. However, sampling of the airways poses a significant challenge, particularly in infants and childre...
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Article
Recurrent copy number variants associated with bronchopulmonary dysplasia
Variability in the incidence and severity of bronchopulmonary dysplasia (BPD) among premature infants suggests that genetic susceptibility plays a role in pathogenesis. An assessment of copy number variants (C...
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Article
Open AccessNext generation sequence analysis of the transcriptional response to neonatal hyperoxia
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Article
Open AccessDefining the effects of prematurity on the lymphocyte transcriptome
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Article
Systems biology approaches to identify developmental bases for lung diseases
A greater understanding of the regulatory processes contributing to lung development could be helpful to identify strategies to ameliorate morbidity and mortality in premature infants and to identify individua...
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Article
Open AccessPeripheral blood gene expression profiles in COPD subjects
To identify non-invasive gene expression markers for chronic obstructive pulmonary disease (COPD), we performed genome-wide expression profiling of peripheral blood samples from 12 subjects with significant ai...
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Article
Open AccessPlatform dependence of inference on gene-wise and gene-set involvement in human lung development
With the recent development of microarray technologies, the comparability of gene expression data obtained from different platforms poses an important problem. We evaluated two widely used platforms, Affymetri...
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Protocol
Progression-Associated Genes in Astrocytoma Identified by Novel Microarray Gene Expression Data Reanalysis
Astrocytoma is graded as pilocytic (WHO grade I), diffuse (WHO grade II), anaplastic (WHO grade III), and glioblastoma multiforme (WHO grade IV). The progression from low- to high-grade astrocytoma is associat...
