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  1. No Access

    Chapter

    Tight Junction Proteins as Emerging Drug Targets: Expanding the Horizons from Inflammation to Cancer

    Tight junctions (TJ), located at the most topical part of the cells, are multi-protein complexes that form a formidable barrier governing the permeability of polarized epithelial and endothelial cells. They pr...

    Sireesha V. Garimella, Rahul Roy… in Tight Junctions in Inflammation and Cancer (2023)

  2. Article

    Open Access

    Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening

    Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) binds to its receptors, TRAIL-receptor 1 (TRAIL-R1) and TRAIL-receptor 2 (TRAIL-R2), leading to apoptosis by activation of caspase-8 and the down...

    Sireesha V Garimella, Kristie Gehlhaus, Jennifer L Dine… in Breast Cancer Research (2014)

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    Article

    Identification of WEE1 as a potential molecular target in cancer cells by RNAi screening of the human tyrosine kinome

    Breast cancers can be classified into those that express the estrogen (ER) and progesterone (PR) receptors, those with ERBB2 (HER-2/Neu) amplification, and those without expression of ER, PR, or amplification of

    Lyndsay M. Murrow, Sireesha V. Garimella… in Breast Cancer Research and Treatment (2010)