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  1. Article

    Open Access

    Genomic insights into the physiology of Quinella, an iconic uncultured rumen bacterium

    Quinella is a genus of iconic rumen bacteria first reported in 1913. There are no cultures of these bacteria, and information on their physiology is scarce and contradictory. Increased abundance of Quinella was p...

    Sandeep Kumar, Eric Altermann, Sinead C. Leahy, Ruy Jauregui in Nature Communications (2022)

  2. Article

    Open Access

    Hydrogen and formate production and utilisation in the rumen and the human colon

    Molecular hydrogen (H2) and formate (HCOO) are metabolic end products of many primary fermenters in the mammalian gut. Both play a vital role in fermentation where they are electron sinks for individual microbes...

    William J. Kelly, Roderick I. Mackie, Graeme T. Attwood in Animal Microbiome (2022)

  3. Article

    Open Access

    Occurrence and expression of genes encoding methyl-compound production in rumen bacteria

    Digestive processes in the rumen lead to the release of methyl-compounds, mainly methanol and methylamines, which are used by methyltrophic methanogens to form methane, an important agricultural greenhouse gas...

    William J. Kelly, Sinead C. Leahy, Janine Kamke, Priya Soni in Animal Microbiome (2019)

  4. Article

    Open Access

    Cultivation and sequencing of rumen microbiome members from the Hungate1000 Collection

    Rumen microbiome biology gets a boost with the release of 410 high-quality reference genomes from the Hungate1000 project.

    Rekha Seshadri, Sinead C Leahy, Graeme T Attwood, Koon Hoong Teh in Nature Biotechnology (2018)

  5. Article

    Open Access

    The complete genome sequence of the rumen bacterium Butyrivibrio hungatei MB2003

    Butyrivibrio hungatei MB2003 was isolated from the plant-adherent fraction of rumen contents from a pasture-grazed New Zealand dairy cow, and was selected for genome sequencing in order t...

    Nikola Palevich, William J. Kelly, Sinead C. Leahy in Standards in Genomic Sciences (2017)

  6. Article

    Open Access

    Gene and transcript abundances of bacterial type III secretion systems from the rumen microbiome are correlated with methane yield in sheep

    Ruminants are important contributors to global methane emissions via microbial fermentation in their reticulo-rumens. This study is part of a larger program, characterising the rumen microbiomes of sheep which...

    Janine Kamke, Priya Soni, Yang Li, Siva Ganesh, William J. Kelly in BMC Research Notes (2017)

  7. Article

    Open Access

    The complete genome sequence of the methanogenic archaeon ISO4-H5 provides insights into the methylotrophic lifestyle of a ruminal representative of the Methanomassiliicoccales

    Methane emissions from agriculture represent around 9 % of global anthropogenic greenhouse emissions. The single largest source of this methane is animal enteric fermentation, predominantly from ruminant lives...

    Yang Li, Sinead C. Leahy, Jeyamalar Jeyanathan in Standards in Genomic Sciences (2016)

  8. Article

    Open Access

    The complete genome sequence of the rumen methanogen Methanobrevibacter millerae SM9

    Methanobrevibacter millerae SM9 was isolated from the rumen of a sheep maintained on a fresh forage diet, and its genome has been sequenced to provide information on the phylogenetic dive...

    William J. Kelly, Diana M. Pacheco, Dong Li in Standards in Genomic Sciences (2016)

  9. Article

    Open Access

    Genomic analysis of three Bifidobacterium species isolated from the calf gastrointestinal tract

    Ruminant animals contribute significantly to the global value of agriculture and rely on a complex microbial community for efficient digestion. However, little is known of how this microbial-host relationship ...

    William J. Kelly, Adrian L. Cookson, Eric Altermann in Scientific Reports (2016)

  10. Article

    Open Access

    The complete genome sequence of Eubacterium limosum SA11, a metabolically versatile rumen acetogen

    Acetogens are a specialized group of anaerobic bacteria able to produce acetate from CO2 and H2 via the Wood–Ljungdahl pathway. In some gut environments acetogens can compete with methanogens for H2, and as a res...

    William J. Kelly, Gemma Henderson, Diana M. Pacheco in Standards in Genomic Sciences (2016)

  11. Article

    Open Access

    The complete genome sequence of the rumen methanogen Methanosarcina barkeri CM1

    Methanosarcina species are the most metabolically versatile of the methanogenic Archaea and can obtain energy for growth by producing methane via the hydrogenotrophic, acetoclastic or met...

    Suzanne C. Lambie, William J. Kelly, Sinead C. Leahy in Standards in Genomic Sciences (2015)

  12. Article

    Open Access

    The complete genome sequence of the rumen methanogen Methanobacterium formicicum BRM9

    Methanobacterium formicicum BRM9 was isolated from the rumen of a New Zealand Friesan cow grazing a ryegrass/clover pasture, and its genome has been sequenced to provide information on the phylogenetic diversity...

    William J Kelly, Sinead C Leahy, Dong Li, Rechelle Perry in Standards in Genomic Sciences (2014)

  13. Article

    Open Access

    Metasecretome-selective phage display approach for mining the functional potential of a rumen microbial community

    In silico, secretome proteins can be predicted from completely sequenced genomes using various available algorithms that identify membrane-targeting sequences. For metasecretome (collection of surface, secreted a...

    Milica Ciric, Christina D Moon, Sinead C Leahy, Christopher J Creevey in BMC Genomics (2014)