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Article
Open AccessDNA methylation patterns of FKBP5 regulatory regions in brain and blood of humanized mice and humans
Humanized mouse models can be used to explore human gene regulatory elements (REs), which frequently lie in non-coding and less conserved genomic regions. Epigenetic modifications of gene REs, also in the cont...
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Article
FKBP5 intron 7 methylation is associated with higher anxiety proneness and smaller right thalamus volume in adolescents
Dysregulation of stress response systems may mediate the detrimental effects of childhood trauma (CT) on mental health. FKBP5 regulates glucocorticoid receptor sensitivity and exerts pleiotropic effects on int...
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Article
Open AccessThe co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus of male mice
Disturbed activation or regulation of the stress response through the hypothalamic-pituitary-adrenal (HPA) axis is a fundamental component of multiple stress-related diseases, including psychiatric, metabolic,...
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Article
Identity domains capture individual differences from across the behavioral repertoire
Personality traits can offer considerable insight into the biological basis of individual differences. However, existing approaches toward understanding personality across species rely on subjective criteria a...
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Article
Open AccessHAM-TBS: high-accuracy methylation measurements via targeted bisulfite sequencing
The ability to accurately and efficiently measure DNA methylation is critical to advance the understanding of this epigenetic mechanism and its contribution to common diseases. Here, we present a highly accura...
