-
Article
Open AccessDNA methylation patterns of FKBP5 regulatory regions in brain and blood of humanized mice and humans
Humanized mouse models can be used to explore human gene regulatory elements (REs), which frequently lie in non-coding and less conserved genomic regions. Epigenetic modifications of gene REs, also in the cont...
-
Article
Open AccessStress-induced brain responses are associated with BMI in women
Overweight and obesity are associated with altered stress reactivity and increased inflammation. However, it is not known whether stress-induced changes in brain function scale with BMI and if such association...
-
Article
Open AccessAssociations of psychiatric disease and ageing with FKBP5 expression converge on superficial layer neurons of the neocortex
Identification and characterisation of novel targets for treatment is a priority in the field of psychiatry. FKBP5 is a gene with decades of evidence suggesting its pathogenic role in a subset of psychiatric pati...
-
Article
Open AccessIdentification of dynamic glucocorticoid-induced methylation changes at the FKBP5 locus
Epigenetic mechanisms may play a major role in the biological embedding of early-life stress (ELS). One proposed mechanism is that glucocorticoid (GC) release following ELS exposure induces long-lasting altera...
-
Article
Open AccessHAM-TBS: high-accuracy methylation measurements via targeted bisulfite sequencing
The ability to accurately and efficiently measure DNA methylation is critical to advance the understanding of this epigenetic mechanism and its contribution to common diseases. Here, we present a highly accura...
