19 Result(s)

Article

A metabolomics study in aqueous humor discloses altered arginine metabolism in Parkinson’s disease

The lack of accessible and informative biomarkers results in a delayed diagnosis of Parkinson’s disease (PD), whose symptoms appear when a significant number of dopaminergic neurons have already disappeared. T...

Joan Serrano-Marín, Silvia Marin, David Bernal-Casas… in Fluids and Barriers of the CNS (2023)

Article

SPIOMET4HEALTH—efficacy, tolerability and safety of lifestyle intervention plus a fixed dose combination of spironolactone, pioglitazone and metformin (SPIOMET) for adolescent girls and young women with polycystic ovary syndrome: study protocol for a multicentre, randomised, double-blind, placebo-controlled, four-arm, parallel-group, phase II clinical trial

Polycystic ovary syndrome (PCOS) is the most prevalent, chronic endocrine-metabolic disorder of adolescents and young women (AYAs), affecting 5–10% of AYAs worldwide. There is no approved pharmacological thera...

Cristina Garcia-Beltran, Rita Malpique, Marianne S. Andersen, Firdevs Bas… in Trials (2023)

Article

Inhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability

Metabolic programs can differ substantially across genetically distinct subtypes of acute myeloid leukemia (AML). These programs are not static entities but can change swiftly as a consequence of extracellular...

Ayşegül Erdem, Silvia Marin, Diego A. Pereira-Martins… in Nature Communications (2022)

Article

The Glycolytic Gatekeeper PDK1 defines different metabolic states between genetically distinct subtypes of human acute myeloid leukemia

Acute myeloid leukemia remains difficult to treat due to strong genetic heterogeneity between and within individual patients. Here, we show that Pyruvate dehydrogenase kinase 1 (PDK1) acts as a targetable dete...

Ayşegül Erdem, Silvia Marin, Diego A. Pereira-Martins… in Nature Communications (2022)

Article

Four thiol-oxidoreductases involved in the formation of disulphide bonds in the Streptomyces lividans TK21 secretory proteins

Bacterial secretory proteins often require the formation of disulphide bonds outside the cell to acquire an active conformation. Thiol-disulphide oxidoreductases are enzymes that catalyse the formation of disu...

Sonia Gullón, Silvia Marín, Rafael P. Mellado in Microbial Cell Factories (2019)

Article

Induction of oxidative metabolism by the p38α/MK2 pathway

Adequate responses to environmental stresses are essential for cell survival. The regulation of cellular energetics that involves mitochondrial energy production and oxidative stress is central in the process ...

Natalia Trempolec, Juan Pablo Muñoz, Konstantin Slobodnyuk… in Scientific Reports (2017)

Article

MIDcor, an R-program for deciphering mass interferences in mass spectra of metabolites enriched in stable isotopes

Tracing stable isotopes, such as ¹³C using various mass spectrometry (MS) methods provides a valuable information necessary for the study of biochemical processes in cells. However, extracting such information re...

Vitaly A. Selivanov, Adrián Benito, Anibal Miranda, Esther Aguilar… in BMC Bioinformatics (2017)

Article

Erratum to: COordination of Standards in MetabOlomicS (COSMOS): facilitating integrated metabolomics data access

Reza M. Salek, Steffen Neumann, Daniel Schober, Jan Hummel, Kenny Billiau… in Metabolomics (2015)

Article

COordination of Standards in MetabOlomicS (COSMOS): facilitating integrated metabolomics data access

Metabolomics has become a crucial phenoty** technique in a range of research fields including medicine, the life sciences, biotechnology and the environmental sciences. This necessitates the transfer of exp...

Reza M. Salek, Steffen Neumann, Daniel Schober, Jan Hummel, Kenny Billiau… in Metabolomics (2015)

Article

Workforce preparation: the Biohealth computing model for Master and PhD students

The article addresses the strategic role of workforce preparation in the process of adoption of Systems Medicine as a driver of biomedical research in the new health paradigm. It reports on relevant initiative...

Marta Cascante, Pedro de Atauri, David Gomez-Cabrero… in Journal of Translational Medicine (2014)

Article

¹³C metabolic flux analysis shows that resistin impairs the metabolic response to insulin in L6E9 myotubes

It has been suggested that the adipokine resistin links obesity and insulin resistance, although how resistin acts on muscle metabolism is controversial. We aimed to quantitatively analyse the effects of resis...

Shirley Guzmán, Silvia Marin, Anibal Miranda, Vitaly A Selivanov… in BMC Systems Biology (2014)

Article

Compartmentation of glycogen metabolism revealed from ¹³C isotopologue distributions

Stable isotope tracers are used to assess metabolic flux profiles in living cells. The existing methods of measurement average out the isotopic isomer distribution in metabolites throughout the cell, whereas t...

Igor Marin de Mas, Vitaly A Selivanov, Silvia Marin, Josep Roca… in BMC Systems Biology (2011)

Article

A Sensitive Method to Monitor Bacillus subtilis and Streptomyces coelicolor-related Bacteria in Maize Rhizobacterial Communities: The Use of Genome-Wide Microarrays

Gema Val, Silvia Marín, Rafael P. Mellado in Microbial Ecology (2009)