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Article
Open AccessPreclinical evaluation of the SARS-CoV-2 Mpro inhibitor RAY1216 shows improved pharmacokinetics compared with nirmatrelvir
Although vaccines are available for SARS-CoV-2, antiviral drugs such as nirmatrelvir are still needed, particularly for individuals in whom vaccines are less effective, such as the immunocompromised, to preven...
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Article
Bacoside a inhibits the growth of glioma by promoting apoptosis and autophagy in U251 and U87 cells
Bacoside A (gypenoside, Gyp) is a potent bioactive compound derived from Gynostemma pentaphyllum, known to exert inhibitory effects on various malignant tumors. However, the effects of Gyp on glioma as well as th...
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Article
Open AccessInhibition of Endoplasmic Reticulum Stress Improves Chronic Ischemic Hippocampal Damage Associated with Suppression of IRE1α/TRAF2/ASK1/JNK-Dependent Apoptosis
Chronic cerebral ischemia is a complex form of stress, of which the most common hemodynamic characteristic is chronic cerebral hypoperfusion (CCH). Lasting endoplasmic reticulum (ER) stress can drive neurologi...
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Article
Open AccessSelective and predicable amine conjugation sites by kinetic characterization under excess reagents
The site selectivity for lysine conjugation on a native protein is difficult to control and characterize. Here, we applied mass spectrometry to examine the conjugation kinetics of Trastuzumab-IgG (Her-IgG) and...
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Article
Open AccessUSP24 promotes drug resistance during cancer therapy
Drug resistance has remained an important issue in the treatment and prevention of various diseases, including cancer. Herein, we found that USP24 not only repressed DNA-damage repair (DDR) activity by decreas...
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Article
Open AccessEndomembrane Protein Trafficking Regulated by a TvCyP2 Cyclophilin in the Protozoan Parasite, Trichomonas vaginalis
In Trichomonas vaginalis, the TvCyP1-catalyzed conformational switches of two glycinyl-prolyl imide bonds in Myb3 were previously shown to regulate the trafficking of Myb3 from cytoplasmic membrane compartments t...
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Article
Open AccessAn examination of home-based end-of-life care for cancer patients: a qualitative study
Only a small number of patients have utilized the home-based end-of-life care service in Shanghai that has been offered since 2012. This study explores how home-based end-of-life care is delivered in community...
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Article
Open AccessFavorable Response to Long-term Nucleos(t)ide Analogue Therapy in HBeAg-positive Patients with High Serum Fucosyl-Agalactosyl IgG
Aberrant IgG glycosylation is a feature of hepatitis B virus (HBV) infection but its effect on a long-term efficacy of antiviral therapy has never been addressed. After a screening of 1,085 patients, 132 eligi...
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Article
Exploring the antecedents and consequences of technology and knowledge integration mechanisms in the context of NPD
In order to provide new products that are more innovative and are suited to customer needs, enterprises have started to look for assistance from external partners. Consequently, as firms launch new product dev...
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Article
Steroid Probes Conjugated with Protein-Protected Gold Nanocluster: Specific and Rapid Fluorescence Imaging of Steroid Receptors in Target Cells
Steroid ligands can easily diffuse through the cell membrane and this property makes it feasible to be used for in-situ staining of the nuclear receptors. However, nonspecific binding of the internalized ligan...
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Article
Open AccessSite-specific covalent modifications of human insulin by catechol estrogens: Reactivity and induced structural and functional changes
Proteins, covalently modified by catechol estrogens (CEs), were identified recently from the blood serum of diabetic patients and referred to as estrogenized proteins. Estrogenization of circulating insulin ma...
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Article
Open AccessAutophagic degradation of aquaporin-2 is an early event in hypokalemia-induced nephrogenic diabetes insipidus
Hypokalemia (low serum potassium level) is a common electrolyte imbalance that can cause a defect in urinary concentrating ability, i.e., nephrogenic diabetes insipidus (NDI), but the molecular mechanism is un...
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Chapter and Conference Paper
The Moderating Roles of Perceived Risks and Social Influences with Regard to the Effects of Consumers’ Perceived Value and Online Purchasing
This study confirms that consumers’ beliefs and perceived value influence significant on their attitudes and behaviors toward online shop**. While perceived risk serves as a negative moderator that can inhib...
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Article
Using hidden Markov models to predict DNA-binding proteins with sequence and structure information
In the post-genome period, the protein domain structures are published rapidly, but they have not been studied comprehensively. To figure out the cell function, the protein–DNA interactions decrypt the protein...
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Article
In-Depth Comparative Characterization of Hemoglobin Glycation in Normal and Diabetic Bloods by LC-MSMS
The glycation level at β-Val-1 of the hemoglobin β chain in human blood (HbA1c%) is used to diagnose diabetes and other diseases. However, hemoglobin glycation occurs on multiple sites on different isoforms wi...
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Protocol
Quantitative NanoProteomics Approach for Protein Complex (QNanoPX) Using Gold Nanoparticle-Based DNA Probe
Affinity purification by pulldown methods using target-bound gel beads provides a powerful approach for purifying endogenous protein complexes. Such methods can be improved by using nanoparticle-based probe, c...
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Chapter and Conference Paper
Eco-innovation by Cross-Field Green Scenario Value-Adding Program
This paper describes a research and development activity of eco-innovation by promoting cross-field green scenario value-adding program in Taiwan. The idea and structure of this eco-innovative R&D model is exp...
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Article
Lessons from Cryptococcal Laccase: From Environmental Saprophyte to Pathogen
Cryptococcus is an opportunistic pathogen that lives in the environment as a free-living yeast and inflicts disease in humans, primarily in immunocompromised patients such as organ-transplant recipients and pe...
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Article
Roles of position, stress, and proficiency in L2 children’s spelling: A developmental perspective
This study investigated the roles of phoneme position, stress, and proficiency in L2 spelling development by Taiwanese students learning English as a Foreign Language (EFL), an alphabetic writing system typolo...
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Article
Map** N-terminus phosphorylation sites and quantitation by stable isotope dimethyl labeling
We have previously coupled stable isotope dimethyl labeling with IMAC enrichment for quantifying the extent of protein phosphorylation in vivo. The enhanced a1 signal of dimethylated peptides served as a unique m...
