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DNA-functionalized artificial mechanoreceptor for de novo force-responsive signaling

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  1. Article

    Open Access

    Global map** of live cell mechanical features using PeakForce QNM AFM

    Atomic force microscopy (AFM) has been widely used to acquire surface topography upon different scanning modes and to quantify mechanical properties of a cell using single-point ramp force mode. However, these...

    **rong Hu, Shenbao Chen, Dandan Huang, Yan Zhang, Shouqin Lü… in Biophysics Reports (2020)

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  2. Article

    Open Access

    Structural Basis for Differences in Dynamics Induced by Leu Versus Ile Residues in the CD Loop of Kir Channels

    The effect of the conserved Leu/Ile site in the CD loop on the gating dynamics of Kir channels and corresponding micro-structural mechanism remains unclear. Molecular dynamics simulations were performed to inv...

    Shouqin Lü, Hailong An, Hailin Zhang, Mian Long in Molecular Neurobiology (2016)

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  3. Article

    Open Access

    Identification of the Conformational transition pathway in PIP2 Opening Kir Channels

    The gating of Kir channels depends critically on phosphatidylinositol 4,5-bisphosphate (PIP2), but the detailed mechanism by which PIP2 regulates Kir channels remains obscure. Here, we performed a series of Targe...

    Junwei Li, Shouqin Lü, Yuzhi Liu, Chunli Pang, Yafei Chen… in Scientific Reports (2015)

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