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Article
Open AccessMETTL3-m6A methylation inhibits the proliferation and viability of type II alveolar epithelial cells in acute lung injury by enhancing the stability and translation efficiency of Pten mRNA
The pathogenesis of acute lung injury (ALI) involves a severe inflammatory response, leading to significant morbidity and mortality. N6-methylation of adenosine (m6A), an abundant mRNA nucleotide modification,...
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Article
Influence of Machine Stiffness on the Portevin–Le Chatelier Effect of Ti-12Mo Alloy Based on a Modified McCormick Constitutive Model
An improved 3D FE model, considering machine stiffness effect and strain dependent parameters in an embedded modified McCormick’s constitutive model, is developed to numerically investigate the spatiotemporal ...
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Article
Numerical analysis on the deformation characteristics and microstructure behaviors of forged IN718 aeroengine drum
This work is motivated by the fact that the microstructures of nickel-based alloy forged parts influenced by hot deformation have a great impact on the mechanical properties of their final parts. In this paper...
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Article
Numerical Analysis on the Spatiotemporal Characteristics of the Portevin–Le Chatelier Effect in Ti-12Mo Alloy
A simplified 3D FE model based on McCormick’s model is developed to numerically predict the spatiotemporal behaviors of the PLC effect in Ti-12Mo alloy tensile tests at 350 °C with strain rates from the order ...
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Article
Correction to: The transcription factor KLF14 regulates macrophage glycolysis and immune function by inhibiting HK2 in sepsis
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Article
Open AccessThe transcription factor KLF14 regulates macrophage glycolysis and immune function by inhibiting HK2 in sepsis
Sepsis is a heterogeneous syndrome induced by a dysregulated host response to infection. Glycolysis plays a role in maintaining the immune function of macrophages, which is crucial for severely septic patients...
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Article
Influence of forging velocity on temperature and phase transformation characteristics of forged Ti-6Al-4V aeroengine drum
This study is prompted by the reality that the forging velocity greatly impacts the phase transformation of titanium forged parts, further affecting the ultimate microstructures and mechanical properties of th...
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Article
Numerical analysis of phase transformation characteristics in hot forging and subsequent air cooling processes of Ti-6Al-4V turbine blade
This work is motivated by the fact that for titanium alloys, the phase transformation characteristics of forged parts decided by hot forging operation have a strong genetic effect on the microstructures of coo...
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Article
Open AccessMicroRNA expression profile of urinary exosomes in Type IV lupus nephritis complicated by cellular crescent
Type IV lupus nephritis (LNIV) is a severe disease characterized by diffuse proliferative lesions, and its prognosis is worse with cellular crescent (LNIV-CC) involvement. Urinary exosomes have been shown to r...
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Article
Effects of Process Parameters on Deformation and Temperature Uniformity of Forged Ti-6Al-4V Turbine Blade
This work is motivated by the frequent occurrence of macro- and microdefects within forged Ti-6Al-4V turbine blades due to the severely nonuniform strain and temperature distributions. To overcome the problem ...
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Article
Effects of friction model on forging process of Ti-6Al-4V turbine blade considering the influence of sliding velocity
This work is motivated by the fact that one key parameter of sliding velocity at die-workpiece interface in numerical analysis of blade forging process is usually ignored, thereby resulting in poor prediction ...
