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Article
Open AccessUnderstanding how junction resistances impact the conduction mechanism in nano-networks
Networks of nanowires, nanotubes, and nanosheets are important for many applications in printed electronics. However, the network conductivity and mobility are usually limited by the resistance between the par...
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Article
Open AccessIncomplete transcripts dominate the Mycobacterium tuberculosis transcriptome
Mycobacterium tuberculosis (Mtb) is a bacterial pathogen that causes tuberculosis (TB), an infectious disease that is responsible for major health and economic costs worldwide1. Mtb encounters diverse environment...
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Article
Open AccessTargeting PAK4 reverses cisplatin resistance in NSCLC by modulating ER stress
Chemoresistance poses a significant impediment to effective treatments for non-small-cell lung cancer (NSCLC). P21-activated kinase 4 (PAK4) has been implicated in NSCLC progression by invasion and migration. ...
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Article
Open AccessQuantitative analysis of printed nanostructured networks using high-resolution 3D FIB-SEM nanotomography
Networks of solution-processed nanomaterials are becoming increasingly important across applications in electronics, sensing and energy storage/generation. Although the physical properties of these devices are...
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Article
Open AccessSmc5/6’s multifaceted DNA binding capacities stabilize branched DNA structures
Smc5/6 is an evolutionarily conserved SMC complex with roles in DNA replication and repair, as well as in viral DNA restriction. Understanding its multiple functions has been hampered by a lack of mechanistic ...
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Article
Open AccessNucleosome-directed replication origin licensing independent of a consensus DNA sequence
The numerous enzymes and cofactors involved in eukaryotic DNA replication are conserved from yeast to human, and the budding yeast Saccharomyces cerevisiae (S.c.) has been a useful model organism for these studie...
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Article
Open AccessTotal neoadjuvant therapy for locally advanced gastric cancer and esophagogastric junction adenocarcinoma: study protocol for a prospective, multicenter, single-arm, phase II clinical trial
Gastric cancer ranks high in terms of morbidity and mortality worldwide. Multimodal therapy is therefore essential for locally advanced gastric cancer. Recent studies have demonstrated that both perioperative ...
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Article
Open AccessChromatin sequesters pioneer transcription factor Sox2 from exerting force on DNA
Biomolecular condensation constitutes an emerging mechanism for transcriptional regulation. Recent studies suggest that the co-condensation between transcription factors (TFs) and DNA can generate mechanical f...
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Article
Open AccessThe iRhom homology domain is indispensable for ADAM17-mediated TNFα and EGF receptor ligand release
Membrane-tethered signalling proteins such as TNFα and many EGF receptor ligands undergo shedding by the metalloproteinase ADAM17 to get released. The pseudoproteases iRhom1 and iRhom2 are important for the tr...
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Article
Optical tweezers in single-molecule biophysics
Optical tweezers have become the method of choice in single-molecule manipulation studies. In this Primer, we first review the physical principles of optical tweezers and the characteristics that make them a p...
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Article
Open AccessA gland-sparing, intraoral sialolithotomy approach for hilar and intraparenchymal multiple stones in the submandibular gland
Multiple intraglandular sialolithiasis for stones deep in the glandular parenchyma may require submandibulectomies, especially if sialendoscopic facilities are unavailable. We describe a gland-sparing intraora...
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Article
Open AccessReversible histone glycation is associated with disease-related changes in chromatin architecture
Cellular proteins continuously undergo non-enzymatic covalent modifications (NECMs) that accumulate under normal physiological conditions and are stimulated by changes in the cellular microenvironment. Glycati...