-
Article
Open AccessUnderstanding how junction resistances impact the conduction mechanism in nano-networks
Networks of nanowires, nanotubes, and nanosheets are important for many applications in printed electronics. However, the network conductivity and mobility are usually limited by the resistance between the par...
-
Article
Open AccessIncomplete transcripts dominate the Mycobacterium tuberculosis transcriptome
Mycobacterium tuberculosis (Mtb) is a bacterial pathogen that causes tuberculosis (TB), an infectious disease that is responsible for major health and economic costs worldwide1. Mtb encounters diverse environment...
-
Article
Open AccessTargeting PAK4 reverses cisplatin resistance in NSCLC by modulating ER stress
Chemoresistance poses a significant impediment to effective treatments for non-small-cell lung cancer (NSCLC). P21-activated kinase 4 (PAK4) has been implicated in NSCLC progression by invasion and migration. ...
-
Article
Open AccessQuantitative analysis of printed nanostructured networks using high-resolution 3D FIB-SEM nanotomography
Networks of solution-processed nanomaterials are becoming increasingly important across applications in electronics, sensing and energy storage/generation. Although the physical properties of these devices are...
-
Chapter and Conference Paper
From Food Security to Thinking About the Conservation of Arable Land in China
With uncertainty over food security due to epidemics, climate change, deteriorating natural resources, and domestic soybean production, arable land conservation was used as an entry point to illustrate how cou...
-
Article
Open AccessSmc5/6’s multifaceted DNA binding capacities stabilize branched DNA structures
Smc5/6 is an evolutionarily conserved SMC complex with roles in DNA replication and repair, as well as in viral DNA restriction. Understanding its multiple functions has been hampered by a lack of mechanistic ...
-
Article
Open AccessNucleosome-directed replication origin licensing independent of a consensus DNA sequence
The numerous enzymes and cofactors involved in eukaryotic DNA replication are conserved from yeast to human, and the budding yeast Saccharomyces cerevisiae (S.c.) has been a useful model organism for these studie...
-
Article
Open AccessTotal neoadjuvant therapy for locally advanced gastric cancer and esophagogastric junction adenocarcinoma: study protocol for a prospective, multicenter, single-arm, phase II clinical trial
Gastric cancer ranks high in terms of morbidity and mortality worldwide. Multimodal therapy is therefore essential for locally advanced gastric cancer. Recent studies have demonstrated that both perioperative ...
-
Article
Open AccessChromatin sequesters pioneer transcription factor Sox2 from exerting force on DNA
Biomolecular condensation constitutes an emerging mechanism for transcriptional regulation. Recent studies suggest that the co-condensation between transcription factors (TFs) and DNA can generate mechanical f...
-
Article
Weakly Supervised Segmentation Loss Based on Graph Cuts and Superpixel Algorithm
In recent years, weakly supervised learning is a hot topic in the field of machine learning, especially for image segmentation. Assuming that only a small number of pixel categories are known in advance, it is...
-
Article
Single-stranded nucleic acid binding and coacervation by linker histone H1
The H1 linker histone family is the most abundant group of eukaryotic chromatin-binding proteins. However, their contribution to chromosome structure and function remains incompletely understood. Here we use s...
-
Article
Enhancement of high entropy oxide (La0.2Nd0.2Sm0.2Gd0.2Y0.2)2Zr2O7 mechanical and photocatalytic properties via Eu do**
High entropy oxides are novel materials with diverse compositions that have received significant interest for their mechanical and photocatalytic properties. In this study, we enhanced the mechanical and photo...
-
Protocol
Probing the Interaction Between Chromatin and Chromatin-Associated Complexes with Optical Tweezers
Single-molecule force spectroscopy is a powerful tool to analyze the architecture and interaction of large macromolecular assemblies that are refractory to high-resolution structural interrogations. Here, we d...
-
Article
Synergy of NTP-La1-xAgxMn1-yCoyO3-δ Hybrid for Soot Catalytic Combustion at Low Temperature
Ag and Co co-doped La1-xAgxMn1-yCoyO3-δ perovskites were prepared by the citric acid sol–gel method. The maximum solubility of Ag+ in LaMnO3 decreased with the increase of Co doped in B-site, which lead to the ex...
-
Article
Open AccessThe iRhom homology domain is indispensable for ADAM17-mediated TNFα and EGF receptor ligand release
Membrane-tethered signalling proteins such as TNFα and many EGF receptor ligands undergo shedding by the metalloproteinase ADAM17 to get released. The pseudoproteases iRhom1 and iRhom2 are important for the tr...
-
Article
Online learning method based on support vector machine for metallographic image segmentation
The shape, size and distribution of the microstructure could certainly reveal mechanical properties. Therefore, it is important to segment the microstructure accurately. However, in view of the randomness in t...
-
Article
Optical tweezers in single-molecule biophysics
Optical tweezers have become the method of choice in single-molecule manipulation studies. In this Primer, we first review the physical principles of optical tweezers and the characteristics that make them a p...
-
Article
Column generation algorithms for mother plate design in steel plants
This paper investigates the mother plate design (MPD) problem which is a typical problem in the production planning of steel plants. The MPD problem refers to a variant of the two-dimensional variable-sized bi...
-
Article
Open AccessA gland-sparing, intraoral sialolithotomy approach for hilar and intraparenchymal multiple stones in the submandibular gland
Multiple intraglandular sialolithiasis for stones deep in the glandular parenchyma may require submandibulectomies, especially if sialendoscopic facilities are unavailable. We describe a gland-sparing intraora...
-
Article
MOF-derived bimetal oxides NiO/NiCo2O4 with different morphologies as anodes for high-performance lithium-ion battery
Bimetal oxides NiO/NiCo2O4 were successfully fabricated by using metal-organic frameworks (MOFs) as the precursor. The prepared NiO/NiCo2O4 showed hollow sphere and rod-like structures, respectively. When evaluat...
