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  1. Article

    Open Access

    Conformational dynamics of cohesin/Scc2 loading complex are regulated by Smc3 acetylation and ATP binding

    The ring-shaped cohesin complex is a key player in sister chromatid cohesion, DNA repair, and gene transcription. The loading of cohesin to chromosomes requires the loader Scc2 and is regulated by ATP. This pr...

    Aditi Kaushik, Thane Than, Naomi J. Petela, Menelaos Voulgaris… in Nature Communications (2023)

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  2. Article

    Open Access

    Smc5/6’s multifaceted DNA binding capacities stabilize branched DNA structures

    Smc5/6 is an evolutionarily conserved SMC complex with roles in DNA replication and repair, as well as in viral DNA restriction. Understanding its multiple functions has been hampered by a lack of mechanistic ...

    Jeremy T-H. Chang, Shibai Li, Emily C. Beckwitt, Thane Than… in Nature Communications (2022)

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  3. No Access

    Article

    A folded conformation of MukBEF and cohesin

    Structural maintenance of chromosomes (SMC)–kleisin complexes organize chromosomal DNAs in all domains of life, with key roles in chromosome segregation, DNA repair and regulation of gene expression. They func...

    Frank Bürmann, Byung-Gil Lee, Thane Than… in Nature Structural & Molecular Biology (2019)