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  1. Article

    Open Access

    Plasma d-asparagine and the d/l-serine ratio reflect chronic kidney diseases in children regardless of physique

    Biomarkers that accurately reflect renal function are essential in management of chronic kidney diseases (CKD). However, in children, age/physique and medication often alter established renal biomarkers. We st...

    Toshimasa Morishita, Naoto Nishizaki, Sakiko Taniguchi, Shinsuke Sakai in Amino Acids (2024)

  2. Article

    Open Access

    Viral entry and translation in brain endothelia provoke influenza-associated encephalopathy

    Influenza-associated encephalopathy (IAE) is extremely acute in onset, with high lethality and morbidity within a few days, while the direct pathogenesis by influenza virus in this acute phase in the brain is ...

    Shihoko Kimura-Ohba, Mieko Kitamura, Yusuke Tsukamoto in Acta Neuropathologica (2024)

  3. Article

    Open Access

    d-Serine as a sensor and effector of the kidney

    d-Serine, a rare enantiomer of serine, is a biomarker of kidney disease and function. The level of d-serine in the human body is precisely regulated through the urinary clearance of the kidney, and its clearance ...

    Tomonori Kimura, Shinsuke Sakai, Yoshitaka Isaka in Clinical and Experimental Nephrology (2023)

  4. Article

    Open Access

    Utility of an image fusion system for 3D preoperative planning and fluoroscopy in the osteosynthesis of distal radius fractures

    Recently, computerized virtual surgery planning has been increasingly applied in various orthopedic procedures. In this study, we developed an image fusion system for 3D preoperative planning and fluoroscopy f...

    Yuichi Yoshii, Yasukazu Totoki in Journal of Orthopaedic Surgery and Research (2019)

  5. Article

    Open Access

    Dynamics of d-serine reflected the recovery course of a patient with rapidly progressive glomerulonephritis

    We experienced a case of a 36-year-old female with rapidly progressive glomerulonephritis (RPGN) due to anti-neutrophil cytoplasmic antibody (ANCA)-associated nephritis and systemic lupus erythematosus (SLE) n...

    Atsushi Hesaka, Keiko Yasuda, Shinsuke Sakai, Hiroaki Yonishi in CEN Case Reports (2019)

  6. Article

    Open Access

    D-Serine reflects kidney function and diseases

    D-Amino acids, long-term undetected enantiomers of L-amino acids, are now emerging as potential biomarkers, especially for kidney diseases. Management of chronic kidney disease (CKD), a global problem with its hi...

    Atsushi Hesaka, Shinsuke Sakai, Kenji Hamase, Tatsuhiko Ikeda in Scientific Reports (2019)

  7. Article

    Open Access

    Encapsulating peritoneal sclerosis in a patient after allogeneic hematopoietic stem cell transplantation: a case report

    Encapsulating peritoneal sclerosis (EPS) is a chronic clinical syndrome of acute or subacute gastrointestinal obstruction seen mainly in patients undergoing peritoneal dialysis. Although there are a few report...

    Yoshimitsu Shimomura, Shinsuke Sakai, Hiroyuki Ueda, Kohei Fujikura in BMC Gastroenterology (2019)

  8. Article

    Open Access

    Reverberant speech recognition combining deep neural networks and deep autoencoders augmented with a phone-class feature

    We propose an approach to reverberant speech recognition adopting deep learning in the front-end as well as b a c k-e n d o f a r e v e r b e r a n t s p e e c h r e c o g n i t i o n s y s t e m, a n d a n o ...

    Masato Mimura, Shinsuke Sakai in EURASIP Journal on Advances in Signal Proc… (2015)

  9. No Access

    Article

    Percutaneous autologous concentrated bone marrow grafting in the treatment for nonunion

    The purpose of this study was to evaluate the clinical and radiographic treatment effects of percutaneous autologous concentrated bone marrow grafting in nonunion cases and to evaluate the effectiveness of th...

    Hisashi Sugaya, Hajime Mishima, Katsuya Aoto in European Journal of Orthopaedic Surgery & … (2014)

  10. No Access

    Article

    Osteomalacia due to Fanconi’s syndrome and renal failure caused by long-term low-dose adefovir dipivoxil

    Homare Shimohata, Shinsuke Sakai, Yujiro Ogawa in Clinical and Experimental Nephrology (2013)

  11. No Access

    Article

    Reaction Pathway Analysis of Homogeneous Dislocation Nucleation in a Perfect Molybdenum Crystal

    Reaction pathway analysis was carried out for homogeneous dislocation nucleation in perfect crystal Mo. The reaction sampling method employed was based on the Nudged Elastic Band algorithm and other extended s...

    Hasan A. Saeed, Satoshi Izumi, Shotaro Hara in MRS Online Proceedings Library (2011)

  12. Article

    Open Access

    Concentrated autologous bone marrow aspirate transplantation treatment for corticosteroid-induced osteonecrosis of the femoral head in systemic lupus erythematosus

    The purpose of this study was to evaluate concentrated autologous bone marrow aspirate transplantation (CABMAT) treatment for corticosteroid-induced osteonecrosis of the femoral head (ONFH) in systemic lupus e...

    Tomokazu Yoshioka, Hajime Mishima, Hiroshi Akaogi in International Orthopaedics (2011)

  13. No Access

    Article

    Development of a tightly-regulated tetracycline-dependent transcriptional activator and repressor co-expression system for the strong induction of transgene expression

    The teteracycline (Tc)-dependent and -inducible transcriptional activator (rtTA) system has been used to express regulated transgene expression in vitro and in vivo. However, previous reports have demonstrated...

    Hiroshi Hosoda, Takahisa Miyao, Shusaku Uchida, Shinsuke Sakai in Cytotechnology (2011)

  14. No Access

    Article

    Effectiveness of bone marrow transplantation for revitalizing a severely necrotic small bone: experimental rabbit model

    Although treating Kienböck disease is controversial, we previously applied a new method that was less invasive and comprised drilling, bone marrow (BM) transplantation, external fixation, and radiating low-int...

    Takeshi Ogawa, Tomoo Ishii, Hajime Mishima in Journal of Orthopaedic Science (2010)

  15. No Access

    Article

    Transition Pathway Analysis of Homogeneous Dislocation Nucleation in a Perfect Silicon Crystal

    Transition pathway sampling was carried out for homogeneous dislocation nucleation in perfect crystal Si. The sampling algorithm employed was Nudged Elastic Band method. Results obtained were compared with cor...

    Hasan A. Saeed, Satoshi Izumi, Shotara Hara in MRS Online Proceedings Library (2010)

  16. No Access

    Article

    Simulations of an Interface Crack Nucleation During Nanoindentaion : Molecular Dynamics and Finite Element Coupling Approach

    We carried out the nanoindentation simulations for the Ru (superlayer) / Cu (film) / SiO2 (substrate) system using the finite temperature MD-FEM coupling method. The calculations are performed for the differen...

    Shotaro Hara, Satoshi Izumi, Shinsuke Sakai in MRS Online Proceedings Library (2008)

  17. No Access

    Chapter and Conference Paper

    Elastic Properties of the Surfaces and Interfaces of Crystal and Amorphous Silicon

    We propose a method to calculate well-relaxed interface/surface properties by using order-parameters to evaluate interface/surface microstructures. Structural relaxation greatly influences the energies of the ...

    Satoshi Izumi, Shotaro Hara in IUTAM Symposium on Mesoscopic Dynamics of … (2004)

  18. No Access

    Article

    Formulation of sensitivity analysis in life cycle assessment using a perturbation method

    In this paper, a new method for the efficient sensitivity analysis in life cycle assessment is proposed. Introduction of a perturbation method to matrix-based life cycle assessment will enable one to evaluate...

    Shinsuke Sakai, Koji Yokoyama in Clean Technologies and Environmental Policy (2002)

  19. No Access

    Chapter and Conference Paper

    On Reliability and Strength of Structural Components against Seismic Excitation

    In the aseismatic design of important structural components in a nuclear power plant and some chemical plants, the related design code demands not only the maximum stress to be suppressed below the plastic col...

    Hiroyuki Okamura, Heki Shibata in Probabilistic Methods in the Mechanics of … (1985)