37 Result(s)

Article

An approach to predict the risk of glaucoma development by integrating different attribute data

Primary open-angle glaucoma (POAG) is one of the major causes of blindness worldwide and considered to be influenced by inherited and environmental factors. Recently, we demonstrated a genome-wide association ...

Yuichi Tokuda, Tomohito Yagi, Kengo Yoshii, Yoko Ikeda, Masahiro Fuwa… in SpringerPlus (2012)

Article

Independent strong association of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe mucosal involvement

Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin and mucous membranes. Cold medicines including non-steroida...

Mayumi Ueta, Nahoko Kaniwa, Chie Sotozono, Katsushi Tokunaga… in Scientific Reports (2014)

Article

Novel common variants and susceptible haplotype for exfoliation glaucoma specific to Asian population

The common variants in lysyl oxidase-like 1 gene (LOXL1) are associated with exfoliation glaucoma (XFG) patients developed through exfoliation syndrome (XFS). However, the risk allele of a variant in LOXL1 has be...

Masakazu Nakano, Yoko Ikeda, Yuichi Tokuda, Masahiro Fuwa, Morio Ueno… in Scientific Reports (2014)

Article

Trans-ethnic study confirmed independent associations of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe ocular surface complications

Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin and mucous membranes. Cold medicines including non-steroida...

Mayumi Ueta, Chitra Kannabiran, Tais Hitomi Wakamatsu, Mee Kum Kim… in Scientific Reports (2014)

Article

JBP485 promotes tear and mucin secretion in ocular surface epithelia

Dry eye syndrome (DES), a multifactorial disease of the tears and ocular surface, is one of the most common ocular disorders. Tear film contains ocular mucins and is essential for maintaining the homeostasis o...

Takahiro Nakamura, Yuiko Hata, Maho Nagata, Norihiko Yokoi… in Scientific Reports (2015)

Article

JBP485 promotes corneal epithelial wound healing

Proper wound healing is vital for maintenance of corneal integrity and transparency. Corneal epithelial damage is one of the most frequently observed ocular disorders. Because clinical options are limited, fur...

Maho Nagata, Takahiro Nakamura, Yuiko Hata, Shumpei Yamaguchi… in Scientific Reports (2015)

Article

Density-gradient centrifugation enables the purification of cultured corneal endothelial cells for cell therapy by eliminating senescent cells

The corneal endothelium is essential for maintaining corneal transparency; therefore, corneal endothelial dysfunction causes serious vision loss. Tissue engineering-based therapy is potentially a less invasive...

Naoki Okumura, Ayaka Kusakabe, Hiroatsu Hirano, Ryota Inoue… in Scientific Reports (2015)

Article

Elevated expression of ABCB5 in ocular surface squamous neoplasia

ATP-binding cassette subfamily B member 5 (ABCB5) is a new member of the ATP-binding cassette superfamily and has been reported as a novel marker for limbal stem cell (LSC), which is essential for corneal home...

Passara Jongkhajornpong, Takahiro Nakamura, Chie Sotozono… in Scientific Reports (2016)

Article

Erratum to: Testosterone stimulates glucose uptake and GLUT4 translocation through LKB1/AMPK signaling in 3T3-L1 adipocytes

Kazuteru Mitsuhashi, Takafumi Senmaru, Takuya Fukuda, Masahiro Yamazaki… in Endocrine (2016)

Article

Rho kinase inhibitor enables cell-based therapy for corneal endothelial dysfunction

The corneal endothelium maintains corneal transparency; consequently, its dysfunction causes severe vision loss. Tissue engineering-based therapy, as an alternative to conventional donor corneal transplantatio...

Naoki Okumura, Yuji Sakamoto, Keita Fujii, Junji Kitano… in Scientific Reports (2016)

Article

Impact of Cigarette Smoking on Tear Function and Correlation between Conjunctival Goblet Cells and Tear MUC5AC Concentration in Office Workers

The first aim of this study was to clarify whether cigarette smoking affects tear secretion, goblet cell density, and tear MUC5AC concentration. The second purpose was to evaluate the correlations of conjuncti...

Yuichi Uchino, Miki Uchino, Norihiko Yokoi, Murat Dogru… in Scientific Reports (2016)

Article

Development of functional human oral mucosal epithelial stem/progenitor cell sheets using a feeder-free and serum-free culture system for ocular surface reconstruction

Ocular surface reconstruction (OSR) using tissue-engineered cultivated oral mucosal epithelial cell sheets (COMECS) is a promising newly developed treatment for patients with severe ocular surface disease. Unt...

Takahiro Nakamura, Seiichi Yokoo, Adams J. Bentley, Maho Nagata… in Scientific Reports (2016)

Article

Efficient and reliable establishment of lymphoblastoid cell lines by Epstein-Barr virus transformation from a limited amount of peripheral blood

Lymphoblastoid cell lines (LCLs) transformed by Epstein-Barr virus (EBV) serve as an unlimited resource of human genomic DNA. The protocol that is widely used to establish LCLs involves peripheral blood mononu...

Natsue Omi, Yuichi Tokuda, Yoko Ikeda, Morio Ueno, Kazuhiko Mori… in Scientific Reports (2017)

Article

Laminin-511 and -521-based matrices for efficient ex vivo-expansion of human limbal epithelial progenitor cells

Optimization of culture conditions for human limbal epithelial stem/progenitor cells (LEPC) that incorporate the in vivo cell-matrix interactions are essential to enhance LEPC ex vivo-expansion and transplantatio...

Naresh Polisetti, Lydia Sorokin, Naoki Okumura, Noriko Koizumi… in Scientific Reports (2017)

Article

Activation of TGF-β signaling induces cell death via the unfolded protein response in Fuchs endothelial corneal dystrophy

Fuchs endothelial corneal dystrophy (FECD) is a slowly progressive bilateral disease of corneal endothelium in which accumulation of extracellular matrix (ECM) and loss of corneal endothelial cells (CECs) are ...

Naoki Okumura, Keisuke Hashimoto, Miu Kitahara, Hirokazu Okuda… in Scientific Reports (2017)

Article

Predictive clinical factors of cystoid macular edema in patients with Descemet’s strip** automated endothelial keratoplasty

The purpose of this present study was to investigate predictive clinical factors associated with cystoid macular edema (CME) post Descemet’s strip** automated endothelial keratoplasty (DSAEK) in a large case...

Koji Kitazawa, Kanae Kayukawa, Koichi Wakimasu, Isao Yokota… in Scientific Reports (2017)

Article

Immunohistochemical Detection of Propionibacterium acnes in the Retinal Granulomas in Patients with Ocular Sarcoidosis

The etiology of sarcoidosis is still obscure; however, Mycobacteria and Propionibacterium acnes are considered the most implicated etiological agent for sarcoidosis. To investigate whether P. acnes is an etiologi...

Kenji Nagata, Yoshinobu Eishi, Keisuke Uchida, Kazuhito Yoneda… in Scientific Reports (2017)

Article

Association of Human Leukocyte Antigen Class 1 genes with Stevens Johnson Syndrome with severe ocular complications in an Indian population

Stevens Johnson syndrome (SJS) is part of a spectrum of adverse drug reactions resulting in the destruction of skin, mucous membranes, and the ocular surface. A similar, more severe form of the disorder includ...

Chitra Kannabiran, Mayumi Ueta, Virender Sangwan, Varsha Rathi… in Scientific Reports (2017)

Article

A new dry eye mouse model produced by exorbital and intraorbital lacrimal gland excision

Chronic dry eye is an increasingly prevalent condition worldwide, with resulting loss of visual function and quality of life. Relevant, repeatable, and stable animal models of dry eye are still needed. We have...

Katsuhiko Shinomiya, Mayumi Ueta, Shigeru Kinoshita in Scientific Reports (2018)