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  1. No Access

    Article

    BDNF improves axon transportation and rescues visual function in a rodent model of acute elevation of intraocular pressure

    Optic neuropathies lead to blindness; the common pathology is the degeneration of axons of the retinal ganglion cells. In this study, we used a rat model of retinal ischemia-reperfusion and a one-time intravit...

    Rui Du, Xu Wang, Shigang He in Science China Life Sciences (2020)

  2. No Access

    Article

    Decreasing intraocular pressure significantly improves retinal vessel density, cytoarchitecture and visual function in rodent oxygen induced retinopathy

    We attempted to explore a noninvasive, easily applicable and economically affordable therapy for retinopathy of prematurity (ROP). Rat pups were raised in 80% oxygen from postnatal day 7 to P12, and returned t...

    Rui Du, Xu Wang, Ke Shen, Shigang He in Science China Life Sciences (2020)

  3. No Access

    Article

    Long-lasting impairments in rodent oxygen-induced retinopathy measured by retinal vessel density and visual function

    In mild or moderate retinopathy of prematurity (ROP), retinal vessels undergo obliteration, proliferation, and regression. Despite complete regression of vessel abnormalities, a variety of visual impairments h...

    Xu Wang, Ke Shen, Fang Lu, Shigang He in Science China Life Sciences (2019)

  4. Article

    Open Access

    Drug addiction is associated with leukocyte telomere length

    Telomeres are protective chromosomal structures that play a key role in preserving genomic stability. Telomere length is known to be associated with ageing and age-related diseases. To study the impairment of ...

    Zhaoyang Yang, Junyi Ye, Candong Li, Daizhan Zhou, Qin Shen, Ji Wu… in Scientific Reports (2013)

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  5. Article

    Direct reprogramming of Sertoli cells into multipotent neural stem cells by defined factors

    Multipotent neural stem/progenitor cells hold great promise for cell therapy. The reprogramming of fibroblasts to induced pluripotent stem cells as well as mature neurons suggests a possibility to convert a te...

    Chao Sheng, Qinyuan Zheng, Jianyu Wu, Zhen Xu, Libin Wang, Wei Li… in Cell Research (2012)

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  6. No Access

    Article

    Properties of mouse retinal ganglion cell dendritic growth during postnatal development

    The property of dendritic growth dynamics during development is a subject of intense interest. Here, we investigated the dendritic motility of retinal ganglion cells (RGCs) during different developmental stage...

    **uLan Yang, **angMing Shi, ShiGang He in Science China Life Sciences (2010)

  7. Article

    Science China In-Sight

    ShiGang He in Science China Life Sciences (2010)

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  8. No Access

    Article

    Change detection by thalamic reticular neurons

    This paper shows that neurons in the thalamic reticular nucleus (TRN) respond strongly to unexpected sounds and convey this information to the auditory thalamus, modulating the responses of medial geniculate b...

    **ong-Jie Yu, **n-**u Xu, Shigang He, Jufang He in Nature Neuroscience (2009)

  9. No Access

    Chapter

    Direction-Selective Ganglion Cells in the Retina

    The first stages in the neuronal processing of image motion take place within the retina. Some types of ganglion cells, which are the output neurones of the retina, are strongly stimulated by image movement in...

    David I. Vaney, Shigang He, W. Rowland Taylor, William R. Levick in Motion Vision (2001)

  10. No Access

    Article

    Retinal direction selectivity after targeted laser ablation of starburst amacrine cells

    Directionally selective retinal ganglion cells respond strongly when a stimulus moves in their preferred direction, but respond little or not at all when it moves in the opposite direction1,2. This selectivity re...

    Shigang He, Richard H. Masland in Nature (1997)