12 Result(s)
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Article
Open AccessRIOK3 sustains colorectal cancer cell survival under glucose deprivation via an HSP90α-dependent pathway
Glucose oxidation via the pentose phosphate pathway serves as the primary cellular mechanism for generating nicotinamide adenine dinucleotide phosphate (NADPH). The central regions of solid tumors typically ex...
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Article
Identification and evaluation of novel serum autoantibody biomarkers for early diagnosis of gastric cancer and precancerous lesion
Early diagnosis is crucial for optimal prognosis of gastric cancer (GC). Hereby, we aimed to identify novel serum autoantibody-based biomarkers for precancerous lesion (PL) and early GC.
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Article
Mucosal Microbiota: Closer to the Pathology, Closer to the Truth?
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Article
Open AccessNon-alcoholic fatty liver is associated with increased risk of irritable bowel syndrome: a prospective cohort study
The relationship between non-alcoholic fatty liver degree as well as non-alcoholic fatty liver disease (NAFLD) and irritable bowel syndrome (IBS) remains poorly understood. We aimed to investigate the prospect...
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Article
Asporin represses gastric cancer apoptosis via activating LEF1-mediated gene transcription independent of β-catenin
Asporin (ASPN) presents in the tumor microenvironment and exhibits a cancer-promoting effect as a stroma protein. Even though ASPN has already been observed inside cancer cells, the functions of intracellular ...
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Article
RBBP8/CtIP suppresses P21 expression by interacting with CtBP and BRCA1 in gastric cancer
RB Binding Protein 8 (RBBP8) was previously reported being involved in DNA double-strand break (DSB) repair in cancers. However, there is no systematic study about the specific functions and related mechanisms...
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Article
Open AccessAssessment of prevalence and risk factors of helicobacter pylori infection in an oilfield Community in Hebei, China
Only a paucity of large-scale perspective and cross-sectional studies on H. pylori infection in China have been published. The purpose of this study was to investigate the prevalence and risk factors for H. pylor...
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Open AccessHMGB1 neutralization is associated with bacterial translocation during acetaminophen hepatotoxicity
Acetaminophen (APAP) hepatotoxicity is associated with a high rate of gram-negative enteric bacterial infection; however, the underlying mechanism is still unknown. APAP overdose induces massive hepatocyte nec...
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Open AccessHigh mobility group B1 impairs hepatocyte regeneration in acetaminophen hepatotoxicity
Acetaminophen (APAP) overdose induces massive hepatocyte necrosis. Necrotic tissue releases high mobility group B1 (HMGB1), and HMGB1 contributes to liver injury. Even though blockade of HMGB1 does not protect...
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Article
Open AccessRinger's lactate improves liver recovery in a murine model of acetaminophen toxicity
Acetaminophen (APAP) overdose induces massive hepatocyte necrosis. Liver regeneration is a vital process for survival after a toxic insult. Since hepatocytes are mostly in a quiescent state (G0), the regeneration...
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Article
Identification of GPX3 Epigenetically Silenced by CpG Methylation in Human Esophageal Squamous Cell Carcinoma
Esophageal squamous cell carcinoma (ESCC) is one of the most common causes of cancer mortality in the gastrointestinal tract. Promoter hypermethylation of tumor suppressor genes contributes to gene inactivatio...
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Genetic variations and haplotypes in TIM-3 gene and the risk of gastric cancer
T cell immunoglobulin and mucin domain-containing molecule 3 (TIM-3) could weaken the Th1-mediated anti-tumor responses and accelerate the tumor cell proliferation by inhabiting the production of IL-2 or IFN-γ...
