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  1. No Access

    Article

    Asporin represses gastric cancer apoptosis via activating LEF1-mediated gene transcription independent of β-catenin

    Asporin (ASPN) presents in the tumor microenvironment and exhibits a cancer-promoting effect as a stroma protein. Even though ASPN has already been observed inside cancer cells, the functions of intracellular ...

    Zheng Zhang, Li Min, Hengcun Li, Lei Chen, Yu Zhao, Si Liu, Qingdong Guo… in Oncogene (2021)

  2. No Access

    Article

    RBBP8/CtIP suppresses P21 expression by interacting with CtBP and BRCA1 in gastric cancer

    RB Binding Protein 8 (RBBP8) was previously reported being involved in DNA double-strand break (DSB) repair in cancers. However, there is no systematic study about the specific functions and related mechanisms...

    Yang Yu, Lei Chen, Gui** Zhao, Hengcun Li, Qingdong Guo, Shengtao Zhu… in Oncogene (2020)

  3. Article

    Open Access

    Cytoplasmic Asporin promotes cell migration by regulating TGF-β/Smad2/3 pathway and indicates a poor prognosis in colorectal cancer

    Previous studies revealed that Asporin (ASPN) is a potential mediator in the development of various types of cancer as a secreted stroma protein, but the function of ASPN inside the cancer cells remains largel...

    Hengcun Li, Zheng Zhang, Lei Chen, **u**g Sun, Yu Zhao… in Cell Death & Disease (2019)

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