-
Article
Open AccessThe use of extracorporeal blood purification therapies and sequential extracorporeal support in patients with septic shock (EROICASS): a study protocol for a national, non-interventional, observational multicenter, prospective study
Septic shock, a critical condition characterized by organ failure, presents a substantial mortality risk in intensive care units (ICUs), with the 28-day mortality rate possibly reaching 40%. Conventional manag...
-
Article
Open AccessBioimpedance-assessed muscle wasting and its relation to nutritional intake during the first week of ICU: a pre-planned secondary analysis of Nutriti Study
Muscle mass evaluation in ICU is crucial since its loss is related with long term complications, including physical impairment. However, quantifying muscle wasting with available bedside tools (ultrasound and ...
-
Article
Open AccessNutritional support and prevention of post-intensive care syndrome: the Italian SIAARTI survey
Malnutrition and muscle wasting are common in ICU patients and predict adverse patient-centered outcomes. The Italian Society of Anesthesia Analgesia Resuscitation and Intensive Care (SIAARTI) conducted a nati...
-
Chapter
Improving of Hemodynamic and Hemostatic in the Golden Hour
The first 60 min after birth, called “golden Hour,” is a critical period for both mother and newborn, who moved from the internal to the external uterine environment. Monitoring trends of vital signs is import...
-
Chapter
Septic Shock in Obstetric Emergency
Sepsis is life-threatening organ dysfunction caused by an unregulated host response to infection, its mortality is 11% of maternal death worldwide.
-
Article
Open AccessImmunological effects of glutamine supplementation in polytrauma patients in intensive care unit
In polytrauma intensive care unit (ICU) patients, glutamine (GLN) becomes a “conditionally essential” amino acid; its role has been extensively studied in numerous clinical trials but their results are inconcl...
-
Article
Open AccessCerebral autoregulation in anoxic brain injury patients treated with targeted temperature management
Little is known about the prevalence of altered CAR in anoxic brain injury and the association with patients’ outcome. We aimed at investigating CAR in cardiac arrest survivors treated by targeted temperature ...
-
Article
Open AccessHigh mobilization of CD133+/CD34+ cells expressing HIF-1α and SDF-1α in septic abdominal surgical patients
The control of endothelial progenitor cells (CD133+/CD34+ EPCs) migrating from bone marrow to peripheral blood is not completely understood. Emerging evidence suggests that stromal cell-derived factor-1α (SDF-...
-
Article
Open AccessPeep titration based on the open lung approach during one lung ventilation in thoracic surgery: a physiological study
During thoracic surgery in lateral decubitus, one lung ventilation (OLV) may impair respiratory mechanics and gas exchange. We tested a strategy based on an open lung approach (OLA) consisting in lung recruitm...
-
Article
Open AccessPlatelet indices and outcome after cardiac arrest
Platelet variables, including platelet distribution width (PDW) and mean platelet volume (MPV), have been associated with outcome in critically ill patients. We evaluated these variables in patients after card...
-
Article
Open AccessImpedance cardiography as tool for continuous hemodynamic monitoring during cesarean section: randomized, prospective double blind study
Impedance Cardiography (ICG) is a non-invasive tool for continuous hemodynamic monitoring. Aims of our study were to assess the utility of ICG to evaluate the hemodynamic impact of 6 mg (GL6) vs 8 mg (GL8) lev...
-
Article
Open AccessCirculating stem cells, HIF-1, and SDF-1 in septic abdominal surgical patients: randomized controlled study protocol
Sepsis caused by complicated intra-abdominal infection is associated with high mortality. Loss of endothelial barrier integrity, inflammation, and impaired cellular oxygen have been shown to be primary contrib...
-
Article
Open AccessHigh mobility group B1 impairs hepatocyte regeneration in acetaminophen hepatotoxicity
Acetaminophen (APAP) overdose induces massive hepatocyte necrosis. Necrotic tissue releases high mobility group B1 (HMGB1), and HMGB1 contributes to liver injury. Even though blockade of HMGB1 does not protect...
