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  1. Article

    Prelimbic Cortical Stimulation Improves Spatial Memory Through Distinct Patterns of Hippocampal Gene Expression in Aged Rats

    Dementia poses major health challenges worldwide, yet current treatments are faced with issues of efficacy and toxicity. Deep brain stimulation (DBS) is a promising non-pharmacological treatment for dementia, ...

    Shawn Zheng Kai Tan, Joveen Neoh, Andrew John Lawrence, Ed Xuekui Wu… in Neurotherapeutics (2020)

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    Article

    Serotonergic treatment normalizes midbrain dopaminergic neuron increase after periaqueductal gray stimulation

    Electrical stimulation of the dorsolateral periaqueductal gray (dlPAG) in rats has been shown to elicit panic-like behaviour and can be a useful as an unconditioned stimulus for modelling anticipatory fear and...

    Shawn Zheng Kai Tan, Yasin Temel, Ariel Yovela Chan… in Brain Structure and Function (2020)

  3. Article

    Open Access

    Immunohistochemical insights into Saffold virus infection of the brain of juvenile AG129 mice

    Saffold Virus (SAFV) is a human cardiovirus that is suspected of causing infection of the central nervous system (CNS) in children. While recent animal studies have started to elucidate the pathogenesis of SAF...

    Shawn Zheng Kai Tan, Mookkan Prabakaran in Virology Journal (2016)

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    Article

    Spatial Learning Requires mGlu5 Signalling in the Dorsal Hippocampus

    We examined the role of hippocampal metabotropic glutamate receptor 5 (mGlu5) in spatial learning and memory. Although it has been shown that mGlu5 signalling is required for certain forms of learning and memo...

    Shawn Zheng Kai Tan, Despina E. Ganella, Alec Lindsay Ward Dick… in Neurochemical Research (2015)