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  1. Article

    Open Access

    Plasma metabolites and physical function in patients undergoing hemodialysis

    Impaired physical function contributes to falls, fractures, and mortality among patients undergoing dialysis. Using a metabolomic approach, we identified metabolite alterations and effect size-based composite ...

    Ranjani N. Moorthi, Sharon M. Moe, Thomas O’Connell in Scientific Reports (2024)

  2. Article

    Open Access

    Relationship between klotho and physical function in healthy aging

    Epidemiological studies have reported a strong association between circulating Klotho and physical function; however, the cohorts were comprised of older adults with multiple comorbidities. Herein, we examined...

    Eliott Arroyo, Cecilia A. Leber, Heather N. Burney, Gayatri Narayanan in Scientific Reports (2023)

  3. Article

    Open Access

    Skeletal muscle metabolic responses to physical activity are muscle type specific in a rat model of chronic kidney disease

    Chronic kidney disease (CKD) leads to musculoskeletal impairments that are impacted by muscle metabolism. We tested the hypothesis that 10-weeks of voluntary wheel running can improve skeletal muscle mitochond...

    Keith G. Avin, Meghan C. Hughes, Neal X. Chen, Shruthi Srinivasan in Scientific Reports (2021)

  4. Article

    Open Access

    Effect of ovariectomy on the progression of chronic kidney disease-mineral bone disorder (CKD-MBD) in female Cy/+ rats

    Male Cy/+ rats have shown a relatively consistent pattern of progressive kidney disease development that displays multiple key features of late stage chronic kidney disease-mineral bone disorder (CKD-MBD), spe...

    Colby J. Vorland, Pamela J. Lachcik, Elizabeth A. Swallow in Scientific Reports (2019)